Low CV Risk, Ages 25-44 & CV/non-CV Outcomes, Ages 65+

描述（由申请人提供）：研究表明，低风险（LR），即所有易于测量的主要危险因素的有利水平，如2010年国家政策建议和目标所定义的（收缩压/舒张压<120/<80 mmHg，血清总胆固醇<200 mg/dl， BMI<25 kg/m2，不吸烟，无糖尿病，无心肌梗死史），临床冠心病/心血管疾病罕见（流行，非流行），估计寿命增加数年，老年人的医疗费用大大降低。重要的知识差距仍有待弥补，特别是关于青年期和中年早期低风险与实现无CVD健康衰老的相关性，即不仅临床而且非侵入性可检测的亚临床CVD较少，更有利的炎症标志物水平可能与CVD相关，以及更高水平的身体表现和身体功能。没有关于这些问题的资料。目的:一般:以一种高效和经济的方式扩展芝加哥心脏协会（CHA）研究数据库，利用新数据进一步对青年/中年早期存在的低风险（LR）长达数十年的后果的知识做出重大贡献，特别是其与实现无创检测亚临床CHD/CVD， CHD/CVD风险炎症标志物的相关性，以及身体表现和功能的损害——在两性和不同种族的经济社会阶层中，包括已经长寿的人（75岁以上）。为了达到目的（一般和特定），将在2006-2009年对年龄在65-79岁之间的年龄在1967-73年25-44岁之间的CHA队列基线(低风险（n=600）和非低风险（n=900）的加权随机样本进行检查。具体目的：评估基线LR状态（25-44岁）与以下因素的长期关系：1)65-79岁亚临床动脉粥样硬化疾病的存在和程度；2) 65 ~ 79岁人群CVD相关炎症标志物水平；3) 65-79岁客观测量的身体表现/功能水平。4)确定当前亚临床动脉粥样硬化疾病和炎症标志物在解释年轻时LR特征与老年时身体表现/功能之间的关系中的作用。意义：从拟议的研究中获得的预期新数据可以为实现2010年健康人计划的两个主要目标——“提高健康生活的质量和寿命”和“消除健康差距”——澄清和告知战略优先事项。

DESCRIPTION (provided by applicant): Background: It has been demonstrated that with low risk (LR), i.e., favorable levels of all readily measurable major risk factors, as defined in national policy recommendations and objectives for 2010 (SBP/DBP <120/<80 mmHg, serum total cholesterol <200 mg/dl, BMI<25 kg/m2, no smoking, no diabetes, no MI history), clinical CHD/CVD is rare (endemic, not epidemic), estimated longevity is increased by several years, and medical care costs in older persons are sizably reduced. Significant knowledge gaps remain to be closed, especially on the relevance of low risk in young adulthood and early middle age for achieving CVD-free healthy aging, i.e., not only less clinical but also less non- invasively detectable subclinical CVD, more favorable levels of inflammatory markers possibly related to CVD, and higher levels of physical performance and physical functioning. Data do not exist on these matters. Aims: General: To expand ~ in an efficient and cost-effective way - the database of the Chicago Heart Association (CHA) Study with new data to make a further major contribution in knowledge about the decades-long consequences of low risk (LR) present in young adulthood/early middle-age, particularly its relevance for achieving freedom in older age from non-invasively detectable subclinical CHD/CVD, inflammatory markers of CHD/CVD risk, and impairment of physical performance and functioning -- in both genders and across SES strata of varied ethnicity including people already long- lived (ages 75+). To achieve Aims (General and Specific), weighted random samples of the CHA cohort baseline ages 25-44 in 1967-73 - low risk (n=600) and not low risk (n=900) - are to be examined in 2006-2009 at ages 65-79. Specific Aims: Assess long-term relationship of baseline LR status (ages 25-44) with: 1) presence and extent of subclinical atherosclerotic disease at ages 65-79; 2) levels of CVD- related markers of inflammation at ages 65-79; 3) levels of objectively measured physical performance/function at ages 65-79. 4) Determine role of current subclinical atherosclerotic disease and inflammatory markers in accounting for associations of LR profile at younger age with physical performance/function at older age. Significance: The expected new data from the proposed research can serve to clarify and inform strategic priorities for attaining the two stipulated Healthy People 2010 primary goals, "increase quality and years of healthy life" and "eliminate health disparities."