Mitochondria and Oxidative Stress in Neurodegenerative Disorders

描述（由申请人提供）：纽约科学院（NYAS）计划于2007年9月26日至29日在纽约科学院举行一次为期3天半的会议，题为“神经退行性疾病中的线粒体和氧化应激”。会议由Gary E. Gibson博士、康奈尔大学威尔医学院神经科学教授和伯克-康奈尔医学研究所、Rajiv R. Ratan医学博士、康奈尔大学威尔医学院神经病学和神经科学伯克教授、伯克-康奈尔医学研究所执行主任和M. Flint Beal医学博士、康奈尔大学威尔医学院神经病学和神经科学系教授兼主席组织。在过去的十年中，我们对线粒体与其他细胞器、转录和检测大分子氧化修饰能力的相互作用的理解有了显著的提高。此外，线粒体和氧化应激的作用在神经退行性疾病的病理生理学中得到了更好的定义。这次会议的目标是确定我们需要知道什么才能找到更好的治疗方法。本次会议将结合基础，临床和转化研究的论坛，旨在提供线粒体功能及其与年龄相关神经退行性疾病及其治疗的关系方面的最新信息。本次会议的具体目标是：1)更好地了解线粒体在神经系统中的作用；2)讨论线粒体在特定神经退行性疾病中的作用；3)解决治疗这些疾病的治疗方法；4)允许学生、研究员和初级研究人员参与到项目中来，并培养他们在他们自己之间以及与更多高级研究人员建立网络的能力；5)通过印刷和电子手段传播会议记录，以便更广泛的受众可以从分享的见解中受益。与年龄相关的神经退行性疾病，如阿尔茨海默病、亨廷顿氏病和帕金森病的发病和进展，强调了衰老、线粒体损伤和氧化应激之间的关系。开发有效的治疗方法需要我们了解线粒体的功能、结构、细胞内和细胞间的氧化信号、氧化应激以及编码线粒体成分的基因的控制。本次会议将为讨论氧化应激及其与神经退行性疾病的关系提供一个论坛。

DESCRIPTION (provided by applicant): The New York Academy of Sciences (NYAS) is planning a major 3 1/2-day conference entitled "Mitochondria and Oxidative Stress in Neurodegenerative Disorders" to be held September 26-29, 2007 at the New York Academy of Sciences, New York, NY. The conference is being organized by Gary E. Gibson, PhD, Professor of Neuroscience, Weill Medical College of Cornell University, and Burke-Cornell Medical Research Institute, Rajiv R. Ratan, MD, PhD, Burke Professor of Neurology and Neuroscience, Weill Medical College of Cornell University, Executive Director, Burke-Cornell Medical Research Institute, and M. Flint Beal, MD, Professor and Chairman, Department of Neurology and Neuroscience, Weill Medical College of Cornell University. Our understanding of the interaction of mitochondria with other cellular organelles, with transcription and in the ability to detect oxidative modification of macromolecules has improved significantly in past decade. Moreover the roles of mitochondria and oxidative stress are better defined in the pathophysiology of neurodegenerative disorders. The goal of the meeting is to determine what we need to know to move towards better therapies. This conference will combine basic, clinical and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment. Specific objectives of this conference are to: 1) develop a better understanding of the role of mitochondrial in the nervous system; 2) discuss the involvement of mitochondria in specific neurodegenerative disorders; 3) address therapeutic approaches to treating these diseases; 4) allow students, fellows and junior investigators to be involved in the program and to foster their ability to form networks amongst themselves and with more senior investigators and 5) disseminate the proceedings by print and electronic means so that a wider audience can benefit from the insights shared. The age-related onset and progression of neurodegenerative disorders such as Alzheimer's disease, Huntington's disease and Parkinson's disease underscores a relationship between aging, mitochondrial impairment and oxidative stress. The development of effective therapies requires that we understand mitochondrial function, structure, intracellular and intercellular oxidant signaling, oxidative stress and the control of genes that code mitochondrial components. This conference will provide a forum for discussion of the state-of-the-art in oxidative stress and its relationship to neurodegenerative diseases.