Apoptotic Cell Recognition & Clearance 2007 Gordon Research Conference

细胞凋亡或程序性细胞死亡发生在我们身体的许多组织中 生活。快速有效地清除凋亡细胞是最后一步，也许 终极目标，即细胞凋亡计划。吞噬作用在胚胎发育过程中也起着关键作用。 发育、正常组织动态平衡和神经元发育。积累证据 表明未能及时清除凋亡细胞会导致严重的后果 炎症和自身免疫性疾病，如系统性红斑狼疮(SLE) 动脉粥样硬化和癌症易感性。 这项提议要求支持两年一度的戈登研究会议 “细胞凋亡的识别和清除”，将于2007年6月17日至22日在贝茨学院举行， 缅因州。这是这一系列会议的第三次会议，前两次会议分别于2003年和2005年举行。 这次会议将吸引基础和临床科学家研究调控机制。 识别和吞噬凋亡细胞，具有即刻和重要的基础 免疫学和临床意义。 由于这是吞没领域唯一的定期会议，会议的目标是 (1)介绍目前在承认等领域核心议题方面取得的进展 分子、信号通路和吞噬机制；(Ii)探索令人兴奋的新课题 随着这一年轻领域的迅速发展而出现的；(Iii)汇聚那些研究 与那些研究生理和病理中的凋亡细胞吞噬的人的核心分子问题 临床领域，如免疫耐受、炎症、肿瘤免疫学和自身免疫； 以及(4)提供自由讨论意见和未公布数据的论坛，以及 为新进入该领域的调查人员提供进一步合作的网络机会。 课程内容包括：调节细胞凋亡的受体和配体。 识别；吞噬细胞吞噬机制；吞噬细胞在过程中和之后的反应 吞噬作用；在模式生物中鉴定新的受体和分子，如 线虫、果蝇和哺乳动物；自身免疫；轴突修剪或清除 小胶质细胞对轴突的损伤；吞噬与癌症易感性的相关性。 这次会议是独一无二的，主题通常不是主要的 关于细胞凋亡或吞噬作用的会议。会议特意每隔一年举行一次， 细胞凋亡会议鼓励所有对细胞死亡感兴趣的人参与。

Apoptosis or programmed cell death occurs in many tissues of our bodies throughout life. The quick and efficient clearance of apoptotic cells is the final step, and perhaps the ultimate objective, of the apoptotic program. Engulfment also plays a key role during embryonic development, normal tissue homeostasis and neuronal development. Accumulating evidence suggests that failure to clear apoptotic cells promptly has serious consequences for inflammation and autoimmune conditions such as systemic lupus erythematosis (SLE), as well as atherosclerosis and cancer predisposition. This proposal requests support for the biennial Gordon Research Conference on "Apoptotic cell recognition and clearance", to be held June 17-22, 2007 at Bates College, Maine. This is the third meeting in this series, and the previous two were held in 2003 and 2005. The conference will attract both basic and clinical scientists investigating mechanisms regulating recognition and engulfment of apoptotic cells, with immediate and significant basic immunological and clinical implications. Since this is the only regular meeting in the engulfment field, the goals of the meeting are: (i) Presentation of current progress on the core subjects of the field such as recognition molecules, signaling pathways and engulfment machinery; (ii) Exploration of exciting new topics that have emerged as this young field develops rapidly; (iii) Bringing together those studying core molecular questions with those studying apoptotic cell engulfment in physiological and clinical areas such as immune tolerance, inflammation, tumor immunology, and autoimmunity; and (iv) Providing a forum for free discussions of opinions and unpublished data, as well as networking opportunity for furthering of collaborations for investigators new to the field. The topics to be covered will include: Receptors and ligands regulating apoptotic cell recognition; Phagocyte engulfment mechanisms; Responses of phagocytes during and after engulfment; Identification of new receptors and molecules in model organisms such as C. elegans and Drosophila, and in mammals; Autoimmunity; Axonal pruning or clearing of damaged axons by microglial cells; and the relevance of engulfment to cancer predisposition. This meeting is unique and the subject matter is not generally represented in the major meetings on Apoptosis or Phagocytosis. The meeting is purposely held in alternative years with the Apoptosis meeting to encourage participation by all of those with an interest in cell death.