2007 Vascular Cell Biology Gordon Research Conference

描述（由申请人提供）： 要求提供资金，以支持将于2007年2月11日至16日在加利福尼亚州文图拉举行的关于“血管生物学”的戈登研究会议。会议将涵盖各种主题，包括血管系统的发展，连接通信，细胞内信号，生殖中的血管生成，血管床的组织规格，蛋白酶和基质，以及血管生成和抗血管生成疗法。会议将汇集代表广泛学科、方法和系统的发言者、讨论者和与会者。会议规模小，非正式的气氛将有利于讨论和互动。最近在控制血管生物学研究方面的发展，如炎症和系统生物学的使用，使这一会议特别及时。意义：血管生物学的研究一直在以惊人的速度进行。近两年来，许多与血管发育和血管生成相关的新分子被发现。这些进展适用于许多疾病，包括癌症、心血管疾病和炎症。在快速发展的领域，及时审查最新发展至关重要。方法：该提案将利用非常成功的戈登会议形式，提供一个促进科学互动的非正式地点和氛围。会议规模相对较小（150名与会者），与会者的多样性使高级和初级调查员能够很好地交流意见。会议将于星期日晚上开始，星期四结束。每一次会议都是专题性的，将由一位讨论负责人主持。将选出31名发言人和7名讨论负责人。主题包括细胞外基质信号，细胞凋亡，血管细胞分化，肿瘤血管生成和肿瘤壁龛，内皮细胞连接和渗透性，免疫学，血管管形成，信号转导和整合。发言者和讨论领导者名单包括该领域的许多领导者（Iruela-Arispe，Hood，Nabel，Simons）。除了讲座，还将从提交的摘要中选择海报。每个实验室只允许张贴两张海报，以鼓励多样性。还将举行海报“竞赛”。这次会议的重点和规模都是独一无二的。参与者的选择将提供来自所有科学家的广泛代表性，包括临床研究者和行业代表。将特别关注妇女和少数民族。会议将广泛宣传，并有一个网站。根据上一次会议的信息（特别是与会者的反馈），以及有关以前与会者的人口统计数据，我们选择了主题和发言人，以实现多样性并解决该领域的新领域（例如系统生物学）。所要求的资金将用于支付会议费和演讲者、主席和共同主席以及15名学生和研究员的差旅费。会议的总费用估计为80，000美元，其中23，500美元将来自GRC主席基金，26，500美元来自行业，其余（30，000美元）来自NIH。Bradford C.伯克医学博士，哲学博士、将是首席研究员他是Gordon Research会议的经验丰富的组织者，曾主持血管紧张素II会议并担任2005年血管生物学会议的副主席。副主席迈克尔·西蒙斯医学博士将协助伯克博士组织和主持会议。工作环境：会议场地在视听支持、无障碍、房间和食物质量、会议室大小以及发言者和与会者之间互动的许多领域方面都有一流的设施。我们相信这将是一个优秀的戈登研究会议的基础上的主题的及时性，组织和节目内容的卓越性，卓越的拟议发言人，和会议设施。

DESCRIPTION (provided by applicant): Funds are requested to support the Gordon Research Conference on "Vascular Biology" to be held February 11-16, 2007 in Ventura, CA. The conference will cover a variety of topics including development of the vascular system, junctional communication, intracellular signaling, angiogenesis in reproduction, tissue specifications of vascular beds, proteases and matrix, and angiogenic and anti-angiogenic therapies. The meeting will bring together speakers, discussants and participants that represent a wide range of disciplines, approaches and systems. The small size of the conference and the informal atmosphere will facilitate discussion and interactions. Recent developments in the study of the control of vascular biology, such as inflammation and the use of systems biology make this a particularly timely meeting. SIGNIFICANCE: The study of vascular biology has been proceeding at a remarkable pace. Many new molecules relevant to vascular development and angiogenesis have been discovered in the last 2 years. These developments have applicability in many diseases including cancer, cardiovascular disease and inflammation. A timely review of the latest developments is essential in the fast moving field. APPROACH: The proposal will utilize the Gordon Conference format, which has been very successful, by providing an informal location and atmosphere that promotes scientific interactions. The relatively small size of the meeting (150 participants) and diversity of participants makes for an excellent exchange of ideas among both senior and junior investigators. The meeting will begin on a Sunday evening and end on Thursday. Each session is thematic and will be chaired by a Discussion Leader. A total of 31 speakers and 7 discussion leaders will be chosen. Topics include extracellular matrix signaling, apoptosis, vascular cell differentiation, tumor angiogenesis and tumor niches, endothelial cell junctions and permeability, immunology, vascular tube formation, and signaling transduction and integration. A listing of speakers and discussion leaders includes many of the leaders in the field (Iruela-Arispe, Hood, Nabel, Simons). In addition to lectures there will be posters selected from submitted abstracts. Only two posters per lab will be permitted to encourage diversity. A poster "contest" will also occur. The meeting is unique in its focus and size. Participants will be selected to provide a broad representation from all scientists including both clinical investigators and representatives from industry. Particular attention will be paid to women and minorities. The conference will be widely advertised and has a web site. Based on information from the previous meeting (esp. feedback from participants), and statistics regarding demographics of the previous participants, we have chosen topics and speakers to achieve diversity and address new areas (e.g. systems biology) within the field. The requested funds will be used to cover meeting fees and travel expenses of the speakers, chair and co-chair as well as 15 students and fellows. Total cost for the conference is estimated at $80,000 of which $23,500 will come from the GRC Chair's fund, $26,500 from industry and the remainder ($30,000) from the NIH. INVESTIGATORS: Bradford C. Berk, M.D., Ph.D., will be the principal investigator. He is an experienced organizer of Gordon Research conferences having chaired the Angiotensin II conference and serving as Vice-chair of the Vascular Biology conference in 2005. The Vice-chair, Michael Simons, M.D., will assist Dr. Berk in organizing and running the conference. ENVIRONMENT: The meeting site has excellent facilities in terms of audiovisual support, accessibility, quality of rooms and food, size of conference rooms, and many areas for interactions among speakers and participants. We believe this will be an excellent Gordon Research conference based on the timeliness of the subject matter, the excellence of the organization and program content, the excellence of the proposed speakers, and the meeting facilities.