Aerobic and Resistance Exercise for Cancer-Related Fatigue During Radiation

描述(申请人提供)：概述：运动心理学家Karen Mustian博士正在申请一项导师职业发展奖，以扩大她的研究技能，并成为一名癌症控制领域的独立研究员。她的目标是帮助理解运动干预措施，以减少癌症治疗的副作用，特别是癌症相关疲劳(CRF)，这是患者最常见的副作用。该项目的理论指导是CRF研究和去适应理论，该理论认为，减少体力活动会导致肌肉质量和力量的丧失，而阻力运动可以改善这两个方面。职业发展计划：马斯蒂安博士之前在运动心理学、行为医学和癌症控制方面的研究和培训提供了坚实的基础，研究技能、癌症控制、整合系统生物学和生理学以及健康技术方面的具体可测量学习的教育计划将加强这一基础。她的主要导师，加里·莫罗博士，30年来一直是癌症控制研究和培训的领导者。他将在癌症和副作用管理以及随机临床试验设计和分析方面贡献专业知识。马斯蒂安博士的合作导师还拥有培训研究人员的非凡经验。爱丽丝·彭特兰医学博士将贡献癌症生物学和跨学科研究方面的专业知识，以创造用于定量评估的健康技术。安妮·麦克蒂尔南，医学博士，博士将贡献运动和癌症方面的专业知识。顾问委员会成员还将为马斯蒂安博士的职业发展贡献他们独特的专业知识。研究计划：拟议的研究项目是一项随机临床试验，旨在扩大可行性研究的积极结果，并检查114名接受放射治疗的乳腺癌患者的居家步行和渐进式阻力锻炼计划对慢性肾功能衰竭的影响。次要研究目标是提供潜在CRF病因的先导性信息，包括与蛋白酶体泛素途径相关的骨骼肌质量减轻、力量变化和炎症反应的失调，以及使用运动数据作为CRF的独立标记物。这些结果将有助于阐明运动对CRF的公共健康影响，帮助为CRF量身定制运动干预措施，为未来的R01研究提供CRF潜在病因和独立标志物的先导数据，并使Mustian博士成功过渡到癌症控制科学的独立研究员和领导者。

DESCRIPTION (provided by applicant): Overview: Karen Mustian, Ph.D., an exercise psychologist, is applying for a mentored career development award to expand her research skills and become an independent investigator in cancer control. Her goal is to contribute to the understanding of exercise interventions for reducing the side effects of cancer treatments, specifically, cancer-related fatigue (CRF); the most prevalent side effect in patients. The proposed project is theoretically guided by CRF research and de/conditioning theory positing reduced physical activity results in loss of muscle mass and strength, and resistance exercise improves both. Career Development Plan: Dr. Mustian's previous research and training in exercise psychology, behavioral medicine, and cancer control provide a strong foundation that will be enhanced by the educational plan of specific measurable learning in research skills, cancer control, integrative systems biology and physiology, and health technology. Her primary mentor, Gary Morrow, Ph.D., has been a leader in cancer control research, and training for 30 years. He will contribute expertise in cancer and side effect management and in randomized clinical trial design and analyses. Dr. Mustian's co-mentors also have exceptional experience training researchers. Alice Pentland, M.D. will contribute expertise in cancer biology, and interdisciplinary research to create health technology for quantitative assessment. Anne McTiernan, M.D., Ph.D. will contribute expertise in exercise and cancer. Advisory board members will also contribute their unique expertise to Dr. Mustian's career development. Research Plan: The proposed research project is a randomized clinical trial to expand the positive findings of a feasibility study and examine the influence of a home-based walking and progressive resistance exercise program on CRF in 114 breast cancer patients undergoing radiation. Secondary research goals are to provide pilot information on potential CRF etiological factors, including skeletal muscle mass loss, strength changes, and dysregulation of inflammatory responses associated with the proteasome ubiquitin pathway, and on the use of actigraphy motion data as an independent marker of CRF. These results will help elucidate the public health impact of exercise on CRF, assist in tailoring exercise interventions for CRF, provide pilot data on potential etiological factors and independent markers of CRF for a future R01 study, and position Dr. Mustian to successfully transition to an independent investigator and leader in cancer control science.