Investigating and targeting EGFR heterogeneity in glioblastoma

胶质母细胞瘤是最常见的成人脑肿瘤，总体存活率很低，部分原因是肿瘤的异质性和对治疗的抵抗力。表皮生长因子受体(EGFR)在胶质母细胞瘤中常见改变，不同的EGFR突变可在单个肿瘤中共存，甚至在单个肿瘤细胞中驱动耐药性。尽管对EGFR的功能进行了深入的研究，但由于缺乏合适的模型，对EGFR异质性在胶质母细胞瘤中的功能影响的深入了解受到阻碍。在这个项目中，我们将使用果蝇和哺乳动物的组织培养来研究EGFR的异质性如何影响胶质母细胞瘤的发生和发展。

Glioblastoma is the most common adult brain tumour, with a dismal overall survival, which is partly due to tumour heterogeneity and treatment-resistance. Epidermal Growth Factor Receptor (EGFR) is commonly altered in glioblastoma and different EGFR mutations can co-occur in a single tumour, and even in a single tumour cell, driving resistance. Despite intense research into EGFR function, insights into the functional impact of EGFR heterogeneity in glioblastoma are hampered by the lack of appropriate models. In this project, we will use the fruit fly Drosophila and mammalian tissue culture to study how EGFR heterogeneity impacts on glioblastoma development and progression.