Genetic of Papilloma-induced Voice Distrubance

从高中开始，我就渴望通过科学在医学上的应用来帮助人们。临床 实践本身是情感上的满足，但智力上的刺激来自科学探索， 临床实践产生的问题。无限的机会，政治稳定和相对安全， 犯罪吸引我从南非来到美国。我的美国公民身份已经获得，我的正式临床 最近完成了儿科耳鼻喉科医生的培训。 现在必须集中注意力发展我的科学技能。有必要熟悉 最新的生命科学技术，同时保持已经获得的技能。在下列领域的教学 遗传学、分子生物学应用和信息管理， 计划在CGS实验室和顾问实验室进行学徒培训。研究 Post MDPhD博士和埃利希博士（中心共同主任）提供指导和故障排除帮助 基因组科学，CGS）将确保我所选择的研究领域的进展，从而使我能够 为独立的职业生涯奠定基础。 CGS由6名首席调查员和20名其他工作人员组成。以及许多其他 这些研究人员已经定位了胃食管反流的基因。该中心配备了 价值超过250万美元的仪器设备，包括：多个用于建筑的机器人平台， 阵列分析;多个高通量自动测序系统，以及集成的 生物信息系统CGS每年获得约200万美元的校外研究支持（90% NIH），并在上级组织阿勒格尼总医院（Allegheny General Hospital） PI一直着迷于缺乏了解的痛苦，复发性呼吸道乳头状瘤病， 希望通过对它的理解来做出贡献。这种疾病很少受到关注， 使儿童发声困难、失语和呼吸困难，并需要他们接受许多手术， 直到最终出现缓解。许多人都接触过致病病毒， 大多数人不会得这种病。最新的基因组学进展使人们能够发现潜在的遗传 对传染源的敏感性。已经建立了合作，以获取和分析 这样一项使命所需的标本。

Since high school, I have had a desire to help people through the application of science to medicine. Clinical practice alone is emotionally gratifying but intellectual stimulation is derived from the scientific exploration of questions generated by clinical practice. Boundless opportunities, political stability and relative safety from crime attracted me to the US from South Africa. My US citizenship has been obtained and my formal clinical training as a pediatric otolaryngologist has recently been completed. Attention must now be directed at developing my scientific skills. It is necessary to become familiar with the latest life sciences techniques, while maintaining the skills already acquired. Didactic teaching in the fields of genetics, molecular biology applications and information management coupled with hands-on apprenticeships within CGS laboratories and those of consultant laboratories are planned. Research mentorship and troubleshooting assistance by Drs. Post MDPhD and Ehrlich PhD (co-directors of the Center for Genomic Sciences, CGS) will ensure progress in my chosen research field and thereby enable me to build the foundation for an independent career. The CGS is powered by 6 principal investigators and 20 other staff members. Amongst many other achievements, these researchers have localized a gene for gastroesophageal reflux. The center is equipped with over $2.5 million worth of instrumentation including: multiple robotic platforms for construction and analysis of arrays; multiple high throughput automated sequencing systems, and an integrated bioinformatics system. CGS receives approximately $2 million/year in extramural research support (90% NIH) and is held in high regard the parent organization, Allegheny General Hospital The PI has been fascinated by the poorly-understood affliction, recurrent respiratory papillomatosis and whishes to make his mark by contributing to its understanding. The disease has received little attention yet it renders children dysphonic, aphonic and dyspneic and requires that they undergo numerous surgical procedures until remission eventually occurs. Many individuals are exposed to the causative viruses but most do not get the disease. The latest genomic advances enable one to discover the underlying genetic susceptibilities to infectious agents. Collaborations have been established to obtain and analyze the specimens necessary for such a mission.