Genetics of melanoma risk factors

较大的痣（黑素细胞痣）计数是已知的黑色素瘤最危险的因素。因此，了解控制痣发展的因素可能导致对黑色素瘤病因学的重要见解。我们将对从双胞胎及其父母身上采集的DNA样本进行分子遗传学分析，目的是找出影响痣、色素沉着和其他黑色素瘤危险因素的主要基因。这项研究的重要性在于，它将显著提高我们对黑色素瘤风险与黑色素瘤之间关系的理解，并可能导致新的预防和治疗干预措施。

A large mole (melanocytic nevi) count is the strongest known risk factor for melanoma. An understanding of the factors governing naevus development may therefore lead to important insights into the etiology of melanoma. We shall carry out molecular genetic analysis of DNA samples collected from twins and their parents with the aim of identifying major genes affecting moliness, pigmentation and other risk factors for melanoma. The importance of this study is that it will significantly advance our understanding of the relationship between moliness and melanoma risk and may lead to new preventative and therapeutic interventions.