Memristor-based neural interface for massively parallel recording and modulation of neural activity

高信噪比、可扩展和微创的完整动物神经系统记录和刺激对于促进对脑功能的理解至关重要。细胞外电极是能够与大型神经元群体连接的最强大工具之一。神经元组织损伤仍然是缩放电极阵列的主要限制因素，并且已经发现与不同电极材料的电极尺寸相关。小直径超微电极（UME）虽然非常理想，但在达到与生物信号的充分耦合、限制杂散信号损耗以及与读出电子器件的物理接口方面提出了重大挑战

High signal-to-noise, scalable and minimally invasive recording and stimulation of the nervous system of intact animals is of fundamental importance to advance the understanding of brain function.Extracellular electrodes are among the most powerful tools capable of interfacing with large neuronal populations. Neuronal tissue damage remains a major limiting factor in scaling electrode arrays and has been found to correlate with electrode size across different electrode materials. Small diameter ultramicroelectrodes (UMEs), while highly desirable, pose significant challenges in reaching sufficient coupling to the bio signal, limiting stray signal loss and physical interfacing with read-out electronics