Integrated Biostatistical Training for CVD Research

描述（由申请人提供）： 该申请提出了一种新颖的，综合的生物统计学博士前培训计划，重点是为心血管疾病研究的职业生涯做好准备。在这个令人兴奋的心血管疾病研究新时代，熟练的生物统计学家严重短缺，无法应对持续和新出现的挑战，这要求进行培训，正式整合多学科环境中合作的目标经验，掌握有效应用复杂生物统计技术和研究新方法开发所需的统计学理论基础，强调沟通和领导能力。该计划将是北卡罗来纳州州立大学（NCSU）和杜克临床研究所（DCRI）统计系的共同努力，利用世界上最大的统计学研究生课程之一与研究机构之间的现有合作关系，该研究机构是同类中最大的，是心血管疾病研究前沿国际知名研究人员的所在地。五年计划将支持多达5名学员，并将涉及统计理论的NCSU严格的研究，包括概率，推断，线性和其他统计模型，测量理论和高级概率，高级统计推断，统计方法，包括临床试验设计/分析，纵向数据分析，生存分析和前沿专题;心血管疾病科学基础方面的培训;研究责任和道德方面的课程工作;以及沟通和领导技能方面的广泛正式和经验培训。学员将逐步被介绍到DCRI心血管疾病研究，发展到一个完整的协作学徒，他们被整合为DCRI项目团队的功能成员。通过这两个学徒和正式的课程和研讨会，学员将开发广泛的工作知识和专业知识在心血管疾病科学，这将使他们能够立即作出贡献，心血管疾病研究完成后，该计划。受训者将被分配一个机构间导师团队，该团队由每个研究中心的主要生物统计学家导师和DCRI的次要临床医生导师组成，他们将在各个方面合作指导他们。论文研究将涉及新的统计方法的开发和评估，这些方法受到学员心血管疾病研究合作中遇到的挑战的启发。

DESCRIPTION (provided by applicant): This application proposes a novel, integrated program for pre-doctoral training in biostatistics focused on preparing trainees for careers in cardiovascular disease research. The critical shortage of skilled biostatisticians equipped to address ongoing and emerging challenges in this exciting new era of cardiovascular disease research calls for training that formally integrates targeted experience in collaboration in a multidisciplinary environment, mastery of the theoretical underpinnings of statistics required for valid application of sophisticated biostatistical techniques and for research on development of new methodology, and strong emphasis on communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NCSU) and the Duke Clinical Research Institute (DCRI), capitalizing on an existing partnership between one of the largest graduate programs in statistics in the world and a research institution that is the largest of its kind and home to internationally-known researchers at the forefront of cardiovascular disease research. The five-year program will support up to 5 trainees and will involve rigorous study at NCSU of statistical theory, including probability, inference, linear and other statistical models, measure theory and advanced probability, and advanced statistical inference, and statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge special topics; training in fundamental aspects of cardiovascular disease science; course work in research responsibility and ethics; and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually, evolving to a full collaborative apprenticeship in which they are integrated as functioning members of DCRI project teams. Through both this apprenticeship and formal courses and seminars, trainees will develop extensive working knowledge and expertise in cardiovascular disease science that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Trainees will be assigned an inter-institutional mentorship team consisting of primary biostatistician mentors at each site and a secondary clinician mentor at DCRI, who will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees cardiovascular disease research collaborations.