Program in Molecular and Cellular Biosciences

描述（由申请人提供）：本申请申请资金用于支持俄勒冈健康与科学大学分子和细胞生物科学（PMCB）项目博士生的培训。这个跨学科项目汇集了来自五个基础科学系（生物化学和分子生物学、细胞和发育生物学、分子和医学遗传学、分子微生物学和免疫学、生理学和药理学）和附属研究所的175名教员，为一年级和二年级研究生提供成为成功的研究科学家所需的理论和实验室基础。该提案将支持目前在PMCB注册的119名博士生中的6名进行头两年的培训。该应用程序的80名培训教师因其在生物物理，分子，细胞和发展方法方面的专业知识而享誉国际，这些方法使用最先进的方法来解决重要而引人注目的生物学问题。值得注意的是，研究生还直接参与了突破性的转化研究，从开发第一个小分子癌症抑制剂（格列卫）到第一个肝干细胞疗法，肥胖症的分子基础，以及开发针对新出现病原体的新疫苗。我们的课程在第一年为合格的学生提供一个共同的、严格的教学基础，并在第二年继续为学生提供专业基础。学生还参加系列研讨会、项目静修、教学，并可能参加科学会议。学生必须在第一年结束时成功通过综合笔试，并在第二年结束时通过资格考试，其中他们准备并捍卫原始研究计划。随后，学生被正式录取到五个参与部门之一进行研究项目，最终获得哲学博士学位。重要的是，OHSU充满活力的研究社区，加上基础和临床研究设施的邻近性，为博士生提供了一个独特的机会，在他们的培训期间形成跨学科合作，并了解他们所从事的基础科学研究与健康的关系。

DESCRIPTION (provided by applicant): This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health & Science University. This interdisciplinary program brings together 175 faculty members from five basic science departments (Biochemistry and Molecular Biology, Cell and Developmental Biology, Molecular and Medical Genetics, Molecular Microbiology and Immunology, and Physiology and Pharmacology) and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support six Ph.D. students out of the 119 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty members in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students also directly participate in ground-breaking translational research, ranging from the development of the first small molecule inhibitor of cancer (Gleevec) to the first liver stem cell therapy, the molecular basis of obesity, and the development of new vaccines for emerging pathogens. Our program offers qualified students a common, rigorous didactic grounding for the first year, and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provide a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic science research that they undertake.