Heart-Lung Physiology: Molecular-Systemic Integration

描述(由申请人提供)： 这是为培训研究生和博士后研究员(医学博士和博士后)心肺生理学的竞争性续签申请，自1999年7月开始运作。这项提议继续侧重于将细胞和分子信息与身体的整体功能相结合的培训。理论基础：研究重点从系统转向细胞和分子生理学，导致在系统生理学方面训练有素的个人稳步下降，与此同时，基因技术和非侵入性生理功能监测方法的进步创造了对该领域受过培训的个人的主要需求。该方案的主要目标仍然是：“1)提供跨学科的训练，重点是综合心肺功能。 在分子、细胞、器官和整个动物或人类层面的系统；2)为心脏呼吸系统的结构和功能提供广泛的基础，强调“解决问题的技能”。拟议的教职员工已经建立了心肺生理学的研究项目，并培养了一批成功的科学家。他们使用了大量的方法来研究心肺系统，从全身生理学到细胞和分子生物学，再到计算建模。他们代表了CWRU医学院的6个基础科学系和2个临床科学系。这一培训计划促进了拟议教员之间已经存在的合作，并继续对CWRU心肺生理学的培训和未来的研究产生重大影响。实习前的学生将被录取到研究生课程中，并将提供专门针对心肺生理学、分子和细胞生物学基础、实验室轮换、研讨会、期刊俱乐部和大型查房和监督研究的综合方面的课程。该项目的博士后实习生分为两类：1)心脏病学和/或肺病临床研究员；2)博士后实习生。对博士后实习生的研究培训有适当的高级课程、研讨会、期刊俱乐部和盛大的轮回。在本期培训中，共招收博士后学员8名，博士后学员7名(博士后4名，博士后3名)，其中一半已顺利完成培训。我们建议的培训计划，强调跨越部门障碍和科学学科，继续培养受过心肺生理学综合方面培训的全面发展的科学家。

DESCRIPTION (provided by applicant): This is a competing renewal application for training graduate students and post-doctoral fellows (MD and Ph.D) in cardio-respiratory physiology that has been in operation since July 1999. This proposal continues to focus on training in integration of cellular and molecular information to the overall function of the body. Rationale: A shift in research emphasis from systems to cellular and molecular physiology has resulted in a steady decline of well trained individuals in systems physiology at a time when genetic technology and non-invasive approaches for monitoring physiological functions have advanced creating a major need for individuals trained in this area. The major goals of this program continues to be: "1) providing training in interdisciplinary sciences with a focus on integrating function of the cardiorespiratory systems at the molecular, cellular, organ, and whole animal or human levels, and 2) provide a broad-based foundation in structure and function of cardio-respiratory systems with an emphasis on "problem-solving skills". The proposed faculty have established research programs in cardio-respiratory physiology and trained a number successful scientists. They employ a vast repertoire of approaches to study cardio-respiratory systems ranging from whole body physiology to cellular and molecular biology to computational modeling. They represent 6 basic science and 2 clinical Science departments at CWRU School of Medicine. This training program facilitate already existing collaborations amongst the proposed faculty and continues to have a major impact on training and future research in cardio-respiratory physiology at CWRU. The pre-doetoral trainees will be enrolled in the graduate program and will be offered courses specifically designed for integrated aspects of cardio-respiratory physiology, fundamentals of molecular and cell biology, laboratory rotations, seminars, journal clubs and grand rounds and supervised research. Post-doctoral trainees in this program are of two kinds: 1) cardiology and/or pulmonary clinical fellows; and 2) Ph.D. post-doctoral trainees. Research training for post-doctoral trainees is supplemented with appropriate advanced courses, seminars, journal clubs, and grand rounds. In the current training period, 8 pre-doctoral trainees and 7 post-doctoral trainees (4 Ph.D's and 3 MDs) have been recruited, and half of them have successfully completed training. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, continues to develop well-rounded scientists trained in integrated aspects of cardio-respiratory physiology.