Molecular Biology and Gene Therapy in Burns and Trauma

描述（由申请人提供）：该培训计划的总体目标是为两名外科住院医师或其他临床院系官员提供两年的重点研究经验，以表达对创伤，损伤，烧伤或炎症研究的职业承诺。该研究项目将侧重于掌握分子生物学、功能基因组学和基因治疗，因为它适用于创伤、败血症和烧伤的炎症研究。该项目将利用医学院在不断扩大的基因治疗、功能基因组学和分子生物学领域的独特优势，以及国家公认的基础科学家和临床医生之间不断发展的合作，致力于培养未来的临床院士。基因治疗基础科学、功能基因组学和分子生物学与炎症研究的结合将针对成人呼吸窘迫综合征（ARDS）、SIRS或脓毒症综合征、缺血/再灌注损伤、伤口延迟愈合和烧伤创面以及中枢神经系统损伤等问题。教员将从佛罗里达大学医学院的外科、妇产科、神经科学、分子遗传学和微生物学院系的基础科学家中挑选，他们将担任实习生的研究导师。来自外科和麻醉科（重症医学）的临床导师将与学员和研究人员互动，以确保学员接触到

DESCRIPTION (provided by applicant): The overall goal of this training program is to provide a focused two year research experience for two surgical residents-in-training or other clinical house officers expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy as it applies to inflammation research in trauma, sepsis and burns. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of gene therapy, functional genomics and molecular biology, as well as the developing collaborations between nationally recognized basic scientists and clinicians dedicated to the training of future clinical academicians. The interface between the basic science of gene therapy, functional genomics and molecular biology, and inflammation research will be targeted to the problems of adult respiratory distress syndrome (ARDS), SIRS or sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, and CNS injury. The faculty will be drawn from basic scientists in the Departments of Surgery, Obstetrics and Gynecology, Neuroscience and Molecular Genetics and Microbiology at the University of Florida College of Medicine, who will serve as research mentors to the trainees. Clinical mentors from the Departments of Surgery and Anesthesiology (Critical Care Medicine) will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine Department of Surgery General Surgery Residency Program. Successful applicants will with the assistance of the Executive Committee identify a research and clinical mentor who will assist in the formulation of a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology and gene therapy. Furthermore, trainees are expected to participate in seminars in the Gene Therapy Center, and in their basic science departments, as well as weekly laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.