Mechanisms of Childhood Infection and Immunity

描述（由申请人提供）：这是华盛顿大学医学院儿科部门机构研究培训补助金的续期申请。长期目标是促进儿科医师和科学家的成长和发展，他们准备追求独立的学术事业，研究儿童感染和免疫方面的重要问题。该提案的具体目的是利用该机构的独特资源，包括传染病研究中心、免疫学中心和普通医学科学部，与参与的儿科医生、基础科学家和临床研究人员一起维持一个培训计划，他们有共同的兴趣，经常进行调查和学术交流。该计划旨在为最初两年的调查提供资金，并强调细胞和分子生物学方法以及严格的临床和流行病学方法的应用，以解决儿童感染和免疫方面的常见问题。学员将有机会获得足够的空间和资源，并将受益于该机构内的众多教育活动，包括教学课程、期刊俱乐部和相关研讨会。项目主管将利用一个执行委员会来选择学员候选人，审查学员的学术进展，并就项目的运作获得持续的建议。在微生物发病机制、免疫学和临床感染性疾病方面，已建立的儿科医师科学家和其他部门的基础和临床研究人员进行了大量合作，为选定的个人提供了一个独特的培训机会，使他们能够将实验方法应用于儿童感染性和免疫性疾病的治疗和预防。因此，该计划应促进新的儿科学者的发展，以引领未来在这些重要的儿童健康领域的进步。

DESCRIPTION (provided by applicant): This is an application for renewal of an Institutional Research Training Grant within the Department of Pediatrics at Washington University School of Medicine. The long-term objective is to foster the growth and development of pediatric physician-scientists who are prepared to pursue independent academic careers investigating important issues in childhood infection and immunity. The specific aim of this proposal is to utilize the unique resources of the institution, including the Center for Infectious Diseases Research, the Center for Immunology, and the Division of General Medical Sciences, to maintain a training program with a participating faculty of pediatricians, basic scientists, and clinical investigators who share common interests and Frequent investigative and scholarly interactions. The program is intended to provide funding for an initial two years of investigation and emphasizes the application of cell and molecular biologic approaches and rigorous clinical and epidemiologic methods to address common issues in childhood infection and immunity. Trainees will have access to sufficient space and resources and will benefit from the numerous educational activities within the institution, including didactic coursework, journal clubs, and relevant seminars. The program director will utilize an executive committee to select candidate trainees, to review the scholarly progress of trainees, and to obtain continuing advice with respect to operation of the program. The substantial collaboration of established pediatric physician-scientists and basic and clinical investigators in other departments pursuing questions in microbial pathogenesis, immunology, and clinical infectious diseases provides a unique opportunity for the training of selected individuals in the application of experimental methods to the treatment and prevention of infectious and immunologic diseases in children. As such, this program should foster the development of new pediatric scholars to lead the way for future advances in these important areas of child health.