Cleveland Training Program in Cardiovascular Research

描述(由申请人提供)： 这是克利夫兰心血管研究培训计划第三次竞争性续签的修订申请。该计划的目标仍然是为6名有前途的博士前实习生和5名打算从事学术研究或其他科学领导职业的高资质医学博士或博士提供心血管基础研究方面的长期杰出培训。培训的重点是与心脏和心血管疾病有关的细胞生理学、生化和生物物理学的基本机制，特别是与动脉硬化、高血压、缺血性心脏病、冠状动脉疾病和心律失常有关的机制。该计划提供了广泛的实验方法和问题的研究在心脏和平滑肌细胞在生理和病理条件下。拟议培训的主要优势是为受训者提供的研究广度，从麻醉动物到蛋白质结构和蛋白质组学--以及一个积极的、高度互动的养育环境。在心脏电生理学、心脏新陈代谢、膜转运和细胞内信号、遗传学和结构生物学方面存在着突出的研究机会。 这一应用程序的培训教师由19名互动、积极和资金充足的教员组成，他们来自克利夫兰所有五大学术机构的几个系：凯斯西储大学医学院、MetroHealth医学中心、克利夫兰大学医院、克利夫兰退伍军人事务医学中心和克利夫兰临床基金会。他们代表了高级调查人员的良好组合，他们拥有证明的培训记录和有前途的新初级教员。培训学院的设施包括50,000平方英尺的研究实验室和900万美元的校外研究经费。学员们提供了十几个优秀的研究生水平的课程，每周各种研讨会和期刊俱乐部，以及其他新颖的教育经验。建立了有效的行政和治理机制，确保为受训人员提供招聘、录取、质量控制和职业安置咨询。 在上一个供资期间，所有职位都以竞争性方式填补。实习生在出版物、培训经验和培训后安置方面的记录仍然是该计划的一大优势。这份修订后的续签申请纳入了几个机构新招聘的教师，同时更加关注心血管研究，并扩大了成像、电生理学和蛋白质组学领域的培训机会。 该计划一直是大学、跨部门和跨机构的主要重点 克利夫兰的心血管研究。拟议的更新将继续促进教职员工和受训人员之间的互动，并扩大心血管研究方面的文化和培训优势。

DESCRIPTION (provided by applicant): This is a revised application for the third competitive renewal of the Cleveland Training Program in Cardiovascular Research. The goal of this program continues to be to the provision of outstanding long-term training in cardiovascular basic research to six promising predoctoral trainees and five highly qualified M.D.s or Ph.D.s who intend to pursue academic research or other science leadership careers. The training focuses on basic mechanisms of cell physiology, biochemistry and biophysics pertinent to heart and cardiovascular disease, in particular, to arteriosclerosis, hypertension, ischemic heart diseases, coronary artery diseases and arrhythmia. The program offers a broad repertoire of experimental approaches and problems of investigation in cardiac and smooth muscle cells both under physiological and pathological conditions. The major strengths of the proposed training are the breadth of research offered to trainees, ranging from the anesthetized animal to protein structure and proteomics--and a positiveand highly interacting, nurturing environment. Outstanding research opportunities exist in cardiac electrophysiology, cardiac metabolism, membrane transport and intracellular signaling, genetics and structural biology. The training faculty on this application consist of 19 interactive, active and well-funded faculty in several departments at all five major academic institutions in Cleveland: Case Western Reserve University School of Medicine, MetroHealth Medical Center, University Hospitals of Cleveland, the Cleveland Veterans Affairs Medical Center and The Cleveland Clinic Foundation. They represent a good mix of senior investigators with demonstrated training records and promising new junior faculty. The facilities of the training faculty comprise 50,000 square feet of research laboratories and $9 million in extramural research dollars. The trainees have available a dozen excellent graduate-level courses, a weekly variety of seminars and journal clubs and other novel educational experiences. An effective mechanism of administration and governance is in place to assure recruitment, admission, quality control and career placement counseling for the trainees. During the previous funding period all the positions were competitively filled. The trainee record in terms of publications, training experience and post-training placement continues to be a major strength of this program. This revised renewal application incorporates newly recruited faculty in several institutions while providing a tighter focus on cardiovascular research and expanded training opportunities in areas of imaging, electrophysiology and proteomics. This program has been the major collegial interdepartmental and interinstitutional focus for basic cardiovascular research in Cleveland. The proposed renewal will continue to facilitate interaction among faculty and trainees and expand the culture and training excellence in cardiovascular research.