In situ structural characterization of membrane proteins for drug development

本项目旨在实现膜蛋白的原位结构分析。膜蛋白在细胞功能中起着至关重要的作用，是重要的药物靶点。了解膜蛋白的运动和功能需要对蛋白质和周围环境都有深入的了解。特别是，脂质包围着膜蛋白，可以调节膜蛋白的结构和功能。这种调节的详细知识在很大程度上仍然未知，阻碍了对此类药物靶点的机制理解和新疗法的发展。

This project aims to enable the in situ structural analysis of membrane proteins. Membrane proteins play a crucial role in cellular function and are key drug targets. Understanding how membrane proteins move and function requires insights into both protein and the surrounding environment. In particular, lipids surround membrane proteins and can modulate their structure and function. Detailed knowledge of this modulation remains largely unknown hindering the mechanistic understanding of such drug targets and the development of novel therapeutics.