Therapeutic Strategies for Neurodegeneration Training Grant

描述(由申请人提供)： 本申请是对RFA-DA-06-008《疾病神经生物学转译研究培训》(T32)的响应。拟议的神经退行性疾病治疗策略培训计划的总体目标是为翻译神经科学领域的成功职业培养有前途的博士后学者(研究生)、博士后学者和临床学者，旨在发现和开发针对破坏性神经退行性疾病或疾病(如脊髓损伤(SCI)、创伤性脑损伤(TBI)、中风和帕金森病(PD))的疾病修正药物和基因疗法。我们将提供关于这些和其他神经退行性疾病的病理生理学和潜在的疾病修改分子靶点的现代研究概念的广泛培训，这些靶点可以推动发现药理和基因治疗策略，通过这些策略可以改善这些疾病的破坏性影响。这些策略将包括“神经保护性”和“神经恢复性”两种方法。每年申请资助5名博士前学者，为期5年。从第二年开始，申请资助1名博士后学者和1名临床实习生。对于后者，其目的是为晚期神经学或神经外科住院医师、临床研究员或年轻助理教授提供为期一年的奖学金，让他们在基础研究实验室进行一年的交叉培训。来自两个基础科学系(解剖学、神经生物学和生理学)、两个临床系(神经病学和神经外科)和三个中心(脊髓和脑损伤研究中心、莫里斯·K·尤德尔帕金森病研究中心和桑德斯-布朗老龄中心)的14名基础科学和5名临床教师将参加此次培训计划。所有受训人员的培训计划都非常强调以翻译为重点的治疗发现基础研究。对于博士后和博士后学者，每个人都将被期望完成一个多方面的临床教程，专门设计与他们研究的疾病焦点相关的。所有受训人员都将有机会参加丰富的教学课程、研讨会、年度翻译研究座谈会以及外部研究和培训课程。将强调招募妇女和少数群体。

DESCRIPTION (provided by applicant): This application is in response to RFA-DA-06-008 entitled Training in Translational Research in Neurobiology of Disease (T32). The overall goal of the proposed Therapeutic Strategies for Neurodegeneration Training Program is to prepare promising predoctoral scholars (graduate students), postdoctoral scholars and clinical scholars for successful careers in translational neuroscience aimed at the discovery and development of disease-modifying pharmacological and genetic therapies for devastating neurodegenerative disorders or diseases such as spinal cord injury (SCI), traumatic brain injury (TBI), stroke, and Parkinson's Disease (PD). We will provide broad-based training in modern research concepts regarding the pathophysiology of these and other neurodegenerative disorders and potential disease modifying molecular targets that can drive the discovery of pharmacological and gene therapeutic strategies by which the devastating effects of these disorders can be ameliorated. These strategies will include both "neuroprotective" and "neurorestorative" approaches. Funding is requested for 5 Predoctoral Scholars each year for 5 years. Beginning in year 2, funds are requested for 1 Postdoctoral Scholar and 1 Clinical Trainee. In the case of the latter, the purpose is to provide a 1 year fellowship for a late stage neurology or neurosurgery resident, a clinical fellow, or a young Assistant Professor to spend a year cross-training in a basic research laboratory. Fourteen basic science and 5 clinical faculty from two basic science departments (Anatomy and Neurobiology and Physiology), two clinical departments (Neurology and Neurosurgery) and three centers (Spinal Cord & Brain Injury Research Center, Morris K. Udall Parkinson's Disease Research Center, and the Sanders-Brown Center on Aging) will participate in this Training Program. The training program for all of the trainees involves a strong emphasis on translationally-focused therapeutic discovery basic research. For the Predoctoral and Postdoctoral Scholars, each will be expected to complete a multi faceted Clinical Tutorial specifically designed to be relevant to the disease focus of their research. All of the trainees will have the opportunity to participate in a rich offering of didactic course work, seminars, annual translationally-oriented research symposia and research externships and training courses. Recruitment of women and minorities will be emphasized.