Training in bacteriology

描述（由申请人提供）：我们不断增长的微生物学家社区已经为指导原核生物学的博士前和博士后学员开发了一个出色的环境。这项工作正在培养高素质的人才，以满足国家和国际上与细菌学和日益严重的新出现和重新出现的细菌性疾病问题有关的优先事项。鉴于我们的计划的增长，无论是在教师和学员方面，我们重新提交这个建议，建立一个新的NIH支持的细菌学培训计划在宾夕法尼亚大学。培训计划将支持2-3个博士学位。每年有一名博士前研究员候选人和一名博士后研究员，使他们能够在主要研究人员指导的12个实验室中的任何一个获得深入的经验，这些主要研究人员研究细菌生理学或人类，动物或植物疾病的重要方面。之所以选择与T32提案相关的培训师，是因为他们在这些领域的研究计划已经建立，得到了NIH或其他联邦赠款的支持，并且/或者在这些主题上发表了大量文章。原核生物社区的优势之一是多样性，已经在这所领先的研究型大学的三个学院和六个部门之间培养了富有成效的科学互动。这组培训师涵盖了细菌研究的主要领域，包括主要细胞外的细菌-宿主相互作用（Weiser，S。pneumoniae和H. influenzae; Binns，A. tumefaciens; Yuk，Bordetella spps; Zhu，V. cholesterol; and Schifferli，E.大肠杆菌和鼠疫杆菌）和细胞内（Goldfine，L.单核细胞增多症; Rubin，M.结核病）病原体、新型疫苗的开发（Paterson、Schifferli和Weiser）、免疫发病机制和细菌作为免疫治疗剂的用途（Paterson、Shen、Yuk）、细菌细胞表面关键组分的结构和功能（Goulian、Daldal、Pohlschroder）和靶细胞的细菌信号传导（Binns、Goulian、Yuk、Zhu）。在过去的八年里，这些培训师共同发表了关于22种细菌的文章，这些文章与他们实验室中的研究主题和技术的广度相结合，为当前和未来的学员提供了许多研究机会。由培训师提供的研究机会，加上强大的机构承诺和广泛和组织良好的培训计划，有望为学生和博士后研究员提供出色的细菌学培训。

DESCRIPTION (provided by applicant): Our growing community of microbiologists has developed an outstanding environment for mentoring pre- and postdoctoral trainees in prokaryotic biology. This effort is now producing highly qualified individuals to meet national and international priorities related to bacteriology and to the growing problems of emerging and re-emerging bacterial diseases. Given the growth of our program, both in terms of faculty and trainees, we resubmit this proposal to establish a new NIH-supported Training Program in Bacteriology at the University of Pennsylvania. The Training Program would support 2-3 Ph.D. candidate predoctoral fellows as well as one postdoctoral fellow per year, enabling them to obtain an in-depth experience in any one of 12 laboratories directed by principal investigators who study important aspects of bacterial physiology or diseases of humans, animals or plants. The trainers associated with this T32 proposal have been selected because their research programs in these areas are well established, being supported by NIH or other federal grants and/or having published extensively on these topics. One of the strengths of the prokaryotic community is a diversity that has already fostered productive scientific interactions between three Schools and six Departments at this leading research university. The group of trainers encompasses the major areas of research on bacteria including bacterial-host interactions of leading extracellular (Weiser, S. pneumoniae and H. influenzae; Binns, A. tumefaciens; Yuk, Bordetella spps; Zhu, V. cholerae; and Schifferli, E. coli and V. pestis) and intracellular (Goldfine, L. monocytogenes; Rubin, M. tuberculosis) pathogens, the development of novel vaccines (Paterson, Schifferli and Weiser), immunopathogenesis and use of bacteria as agents in immunotherapy (Paterson, Shen, Yuk), the structure and function of key components bacterial cell surface (Goulian, Daldal, Pohlschroder) and bacterial signaling of target cells (Binns, Goulian, Yuk, Zhu). These trainers have together published articles on over twenty-two bacterial species in the past eight years, which, in conjunction with the breadth of research topics and techniques available in their laboratories, offers numerous research opportunities for current and future trainees. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well-organized training program promises to provide excellent training in bacteriology to both students and postdoctoral fellows.