Cu-catalysed Amination of Alkylboron Reagents

这个博士项目的目的是开发铜催化的烷基硼酸酯的胺化方法，并研究它们在生物系统中的潜在应用。烷基硼是有机合成中有价值的试剂，因为它们作为有机分子的构建块具有广泛的性质。这些化合物在空气和湿气中稳定，并与各种官能团表现出广泛的相容性和反应性。Partridge小组致力于通过烷基硼酸酯和胺的相互作用来开发新的C-N键形成反应，从而生成含胺的化合物。这种化学对合成具有生物活性的化合物特别有用，包括药品、农用化学品和天然产品。这项研究的结果预计将对制药和快速发展的生物科学部门产生重大影响。通过发现和准备探索生物系统的探针和开发新的治疗方法，该项目对英国的经济和人民的健康和福祉至关重要。鉴于英国在有机硼化学方面的专业知识，该项目有望进一步提高英国在该领域的国际声誉。通过这个博士项目，学生将获得合成有机化学和催化方面的广泛经验，包括多步骤合成、方法学和化合物表征的分析技术。开发的化学预计将主要应用于农用化学品和制药工业。

The aim of this Ph.D. project is to develop Cu-catalyzed methods for the amination ofalkylboronic esters and to investigate their potential applications in biological systems.Alkylborons are valuable reagents in organic synthesis, owing to their versatileproperties as building blocks for the preparation of organic molecules. These compoundsare stable in air and moisture and exhibit broad compatibility and reactivity with variousfunctional groups. The Partridge group has directed its efforts toward developing novelC-N bond-forming reactions through the interaction of alkylboronic esters and amines,thereby generating amine-containing compounds. This chemistry is particularly useful forsynthesizing biologically active compounds, including pharmaceuticals, agrochemicals, andnatural products.The outcomes of this research are expected to have significant implications for thepharmaceutical and rapidly expanding bioscience sectors. By enabling the discovery andpreparation of probes for exploring biological systems and developing new treatments, theproject is crucial for the UK's economy and the health and wellbeing of its population.Given the strength of the UK's organoboron chemistry expertise, this project isanticipated to further enhance the country's reputation in this area internationally.Through this Ph.D. project, students will acquire extensive experience in syntheticorganic chemistry and catalysis, encompassing multi-step synthesis, methodology, andATAS CERTIFICATEanalytical techniques for compound characterization. The developed chemistry is expectedto find applications primarily in the agrochemical and pharmaceutical industries.