Genomic approaches for understanding resistance to polymyxins in carbapenem-resistant Enterobacteriaceae

细菌中的抗生素耐药性是一个主要的全球健康问题。多粘菌素是用于治疗所有其他类别的细菌感染的抗生素。对多粘菌素耐药的细菌越来越受到关注，但对这种形式的抗生素耐药性知之甚少。在这个项目中，我们将对耐多粘菌素的细菌进行基因测序，以了解耐药性是如何发展的，并了解这些细菌是否在医院的患者之间传播。

Antibiotic resistance in bacteria is a major global health problem. Polymyxins are antibiotics used to treat bacterial infections to all other classes. Bacteria resistant to polymyxins are increasingly noted but little is known about this form of antibiotic resistance. In this project, we will carry out genetic sequencing of bacteria resistant to polymyxins to learn about how resistance develops and to understand whether these bacteria are being transmitted between patients in hospitals.