Training Program in Nephrology Research

描述（由申请人提供）： 本提案旨在支持犹他州健康科学中心大学的肾脏病学培训项目，以提供四个博士后职位，包括两名博士和两名博士后。和医学博士在五年的时间里。肾脏病学培训计划由几组广泛互动的研究者组成。有14位导师和18位合作者参与其中。许多研究者位于成人和儿童肾脏科，但也有研究者在人类遗传学，病理学，医学信息学，生理学，神经生物学和解剖学，生物工程学部门，以及心脏病学，内分泌学，肺和流行病学部门。主要研究组分为：1）集合管生物学，包括内皮素、一氧化氮、肾上腺素、活性氧和嘌呤能系统在调节健康和高血压集合管和髓质功能中的作用; 2）急性肾衰竭，研究缺血性、药物诱导和毒素诱导的急性肾衰竭模型的病理生理学; 3）慢性肾功能衰竭的进展，研究糖尿病肾病、慢性环孢素肾病和系膜增生性GN模型中肾纤维化的机制; 4）肾脏发育，强调相关的转录调控途径;和5）ESRD和慢性肾功能不全，涉及结局、干预和病理生物学分析。学员可以参与临床或基础研究项目。所有受训人员都将接受多层面的培训。临床研究实习生参加K-30计划，其中他们接触到各种各样的临床研究项目。基础研究人员的学员经历了一个庞大的教师群体与互补的研究兴趣。所有受训人员至少花两年时间专门从事研究。

DESCRIPTION (provided by applicant): This proposal is for support of a Nephrology Training Program at the University of Utah Health Sciences Center for four postdoctoral positions, involving both Ph.D.'s and M.D.'s, over a five year period. The Nephrology Training Program consists of several groups of investigators who extensively interact. There are 14 preceptors and 18 collaborators involved. Many investigators are located within the Divisions of Adult and Pediatric Nephrology, however there are investigators in the Departments of Human Genetics, Pathology, Medical Informatics, Physiology, Neurobiology and Anatomy, and Bioengineering, as well as the Divisions of Cardiology, Endocrinology, Pulmonary and Epidemiology. The major research groups are organized into those investigating: 1) collecting duct biology, involving the roles of endothelins, nitric oxide, prostaglandins, reactive oxygen species and the purinergic system in regulating collecting duct and medullary function in health and in hypertension; 2) acute renal failure, studying the pathophysiology of ischemic, drug-induced, and toxin-induced acute renal failure models; 3) progression of chronic renal failure, studying the mechanisms of renal fibrosis in models of diabetic nephropathy, chronic cyclosporine nephropathy, and mesangial proliferative GN; 4) renal development, emphasizing relevant transcriptional regulatory pathways; and 5) ESRD and chronic renal insufficiency, involving analysis of outcomes, interventions and pathobiology. Trainees can become involved in either clinical or basic research projects. All trainees will experience a multidimensional approach to their training. Clinical research trainees are enrolled in the K-30 program wherein they are exposed to a wide variety of clinical research projects. Basic researcher trainees experience a large faculty group with complementary research interests. All trainees spend at least two years devoted to research.