Renal Molecular Cell Biology Training Program

描述(由申请人提供)：这是一个肾病学培训计划的建议，其目标是培养具有进行肾病学基础、翻译和临床研究的必要技能的内科医生。该计划的一个统一主题是先进的光学显微镜成像技术，用于研究四个广泛的领域：)缺血引起的肾上皮损伤，2)常染色体显性遗传性多囊肾病，3)代谢性骨骼疾病和4)上皮细胞极化。这一计划旨在增加高度积极的教师之间的动态互动，创造了一个高度互动、智力刺激的环境。该项目现在提供了三条培养医生-科学家的途径，1)具有两年基础研究要求的肾病培训项目，2)通过医学部由ABIM赞助的临床医生研究员项目提供的博士学位授予项目，以及3)临床研究硕士学位项目。后一项计划旨在培训研究员执行和完成临床研究项目的细节。该计划从一开始就利用了从事共同研究主题的医学博士和博士的联合教师。由此产生的环境导致了对内科科学家的加强培训。医学博士学位提供了对疾病相关过程的洞察，而博士学位则提供了更好的解决问题的洞察力和对科学数据的严格评估。这项建议寻求建立一个培训内科科学家的记录，并增加肾脏学实习生的教育机会。我们计划招募对肾脏疾病病因学和分子细胞生物学感兴趣的医学博士和医学博士。根据所选择的培训途径，该计划将花费至少三年的时间，最多可能花费七年的时间在攻读博士学位的同时进行肾脏病学的亚专业培训。这个高度互动的内科医生和博士小组在肾脏病理生理学方面有着共同的兴趣。该项目非常适合于有效地招聘代表人数不足的少数族裔，因为我们的教职员工中有少数族裔的榜样。这笔赠款将扩大我们教员与细胞和综合生理学、生物化学/分子生物学、微生物学/免疫学和解剖学/细胞生物学系的工作关系。通过这样做，我们的教职员工将增加他们与研究生、博士后研究员、医学生和医学住院医生的互动。我们建议每个财政年度培训三名博士后研究员。

DESCRIPTION (provided by applicant):This is a proposal for a nephrology training program whose goal is to develop physicians with the requisite skills to perform basic, translational and clinical research in nephrology. A unifying theme for the program is advance light microscopy imaging techniques which is utilized to study four broad areas;) ischemia induced renal epithelial injury, 2) autosomal dominant polycystic kidney disease, 3) metabolic bone disease and 4) epithelial cell polarity. This program seeks to increase the dynamic interactions of a highly motivated faculty that has created a highly interactive, intellectually excitng environment. This program now offers three pathways to train physician-scientist, 1) a nephrology training program with a two-year basic research requirement, 2) a PhD degree granting program offered through the Department of Medicine's ABIM sponsored Clinician Investigator program and 3) a Masters in Clinical Research degree program. The later program is designed to train fellows in the details of performing and completing clinical research projects. This program from its inception has utilized combined faculty of MDs and PhDs working on common research themes. The resulting environment has resulted in enhanced training for physician-scientists. MDs provide insights into disease-related processes while PhDs offer improved problem solving insights and rigourous evaluation of scientific data. This proposal seeks to build upon a record to training physician-scientists and to enhance the educational opportunities for nephrology trainees. We envision recruitment of MDs and MD/PhDs with an interest in renal disease pathogensis and molecular cell biology. Depending upon the training pathway selected, a minimum of three years will be spent in the program and up to seven years may be spent in the pursuit of a PhD degree along with Nephrology subspeciality training. This highly interactive group of physicians and PhDs share common interest in renal pathophysiology. The program is idealy suited to effectively recruit under represented minorities, since we have minority role models on the faculty. This grant will extend the working relationships of our faculty with the departments of Cellular and Integrative Physiology, Biochemistry/Molecular Biology, Microbiology/Immunology and Anatomy/Cell Biology. By doing so, our faculty will increase their interactions with graduate students, post-doctoral fellows, medical students and medicine residents. We propose to train three postdoctoral fellows each fiscal year.