Diabetes Endocrine and Metabolic Diseases

描述(由申请人提供)： 这是对我们在糖尿病、内分泌学和代谢性疾病方面的长期培训计划的一次竞争性更新。在最近一个资助周期中，每年约有5名博士后研究员得到资助。共有13名学员在10个不同的实验室工作，得到了支持。该项目旨在容纳博士科学家和拥有医学博士或医学博士学位的内科科学家，他们中的大多数人都是通过宾夕法尼亚大学内分泌学、糖尿病和新陈代谢的临床团契计划进入的。在上一期由T32资助的13名博士后学员中，有8名已经“毕业”，5名目前正在接受资助。其中一名放弃了培训补助金的研究员由于意外需要离开该国，不得不过早地这样做。在其他七人中，有三人获得了独立的KO8资助，目前是宾夕法尼亚大学医学院的医学讲师。两人已返回诊所，计划在临床内分泌学培训后继续研究，一人已通过个人NRSA机制获得独立资金，一人已在私营行业任职。我们要求继续为每年五名研究员提供支助，因为我们预计大多数研究员将获得两年的资助，尽管也有一到三年。在接下来的一段时间里，我们请求额外的支持，允许这五名研究员中的一人接受与糖尿病或内分泌学相关的临床流行病学的专门培训，这是一个新计划的一部分，该计划将这笔培训补助金与宾夕法尼亚大学临床流行病学硕士计划整合在一起。我们还首次要求提供足够的资金，以支持三名博士前学生在研究生院的第三年到第五年期间在该项目领域工作。目前，在我们的培训师指导的实验室里，有36名学生在努力撰写他们的博士论文，大多数人专注于与这一T32任务相关的问题，没有培训补助金的支持。6人(17%)是代表性不足的少数民族。我们的25名培训教员在9个医学院院系设有初级教职，包括15名教授、7名副教授和3名助理教授。培训教员中有六名女性，一名非裔美国人。导师人数的显著增加主要与临床流行病学培训轨道的建立有关。然而，宾夕法尼亚大学的两名新教职员工也被任命为培训补助金。培训资助教师为该项目带来了p细胞发育和功能、激素作用、生理学、糖尿病并发症、人类和模式生物遗传学、转录调控、以患者为导向的研究、流行病学和生物统计学方面的专业知识。这一培训计划继续为那些致力于糖尿病、内分泌学和新陈代谢研究的科学家提供极好的准备。

DESCRIPTION (provided by applicant): This is a competitive renewal for our longstanding Training Program in Diabetes, Endocrinology and Metabolic Diseases. During the most recent funding cycle, about 5 postdoctoral fellows were supported each year. A total of 13 trainees working in 10 different labs have been supported. The program is designed to accommodate both Ph.D. scientists as well as physician scientists with M.D. or M.D, Ph.D. degrees, of whom most enter through the Penn Clinical Fellowship Program in Endocrinology, Diabetes and Metabolism. Of the 13 postdoctoral trainees supported by this T32 during the last period, 8 have "graduated" while 5 are currently supported. One of the fellows who gave up the training grant had to do so prematurely due to an unexpected need to leave the country. Of the other seven, three have obtained independent KO8 funding and are presently Instructors in Medicine at the University of Pennsylvania School of Medicine. Two have returned to the clinic with plans to continue research following training in Clinical Endocrinology, one has obtained independent funding through the individual NRSA mechanism, and one has taken a position in private industry. We ask for a continuation of support for five fellows per year, anticipating that most fellows will receive two years of funding, though some one or three. For the next period, we request additional support to allow one of these five fellows to undertake specialized training in Clinical Epidemiology related to diabetes or endocrinology as part of a new program that integrates this training grant with the University of Pennsylvania Masters of Clinical Epidemiology Program. We also request, for the first time, sufficient funds to support three predoctoral students working in the areas of this program during their third through fifth years of graduate school. At present, there are in laboratories directed by our trainers 36 students working towards their Ph.D. theses, the majority focusing on problems relevant to the mission of this T32 and unsupported by training grants. Six (17%) are underrepresented minorities. Our 25 training faculty have primary appointments in nine Medical School Departments and consist of 15 professors, 7 associate professors, and assistant 3 professors. Six members of the training faculty are woman and one is African- American. The significant expansion in the number of mentors relates primarily to the institution of the training track in Clinical Epidemiology. However, two faculty members new to Penn have also been appointed to the training grant. Training grant faculty bring to the program expertise in p-cell development and function, hormone action, physiology, diabetic complications, genetics in humans and model organisms, transcriptional regulation, patient oriented research, epidemiology and biostatistics. This training program continues to provide superb preparation for those scientists committed to careers in research into diabetes, endocrinology and metabolism.