"Heating-up" the immune microenvironment in paediatric high-grade glioma with combination immunotherapy

免疫细胞有可能选择性地根除高危儿科脑肿瘤，如儿科型弥漫性高级别胶质瘤（PDHGG）。我们的目的是表征PDHGG分子亚群的肿瘤免疫微环境（TIME），探索不同位置和不同分子特征肿瘤之间的免疫异质性。我们的目标是确定如何利用这一点来提高溶瘤病毒治疗的疗效，溶瘤病毒治疗是一种有前途的免疫治疗策略，能够直接裂解肿瘤细胞和免疫刺激。我们的目标是选择溶瘤病毒和分子靶向治疗的免疫治疗组合，可以“加热”一个“冷”的时间，为早期试验确定新的策略。

Immune cells have the potential to selectively eradicate high-risk paediatric brain tumours such as paediatric-type diffuse high-grade glioma (PDHGG). We aim to characterize the tumour immune microenvironment (TIME) of molecular subgroups of PDHGG, exploring immunological heterogeneity between tumours in different locations and with distinct molecular signatures. We aim to determine how this may be exploited to enhance efficacy of oncolytic virotherapy, a promising immunotherapeutic strategy capable of both direct tumour-cell lysis and immune stimulation. We aim to select immunotherapy combinations of oncolytic virus and molecular targeted therapeutics that can "heat-up" a "cold" TIME, identifying novel strategies for early phase trials.