Resveratrol & Natur Polyphenols: Mech of Proteolitic Clear of AB/Marambaud, Phil

一致的流行病学研究表明，适量饮用葡萄酒可以降低患病风险。 罹患阿尔茨海默氏症的可能性。葡萄酒中含有大量的抗氧化剂多酚， 怀疑对阿尔茨海默病患者饮酒有益。尽管 对这些多酚的生物利用度持怀疑态度，最近的活体数据清楚地表明 天然多酚白藜芦醇在啮齿动物应激模型中的神经保护作用 和疾病，因此，一项对阿尔茨海默病患者进行的安全性-有效性研究 白藜芦醇目前在西奈山医学院进行。然而，确切的分子 白藜芦醇和其他天然多酚对心脏的有益作用机制 阿尔茨海默病脑内神经退行性变的过程尚不清楚。我们最近的数据显示 结果显示，白藜芦醇(Frans-3，4‘，5-三羟基二苯乙烯)可显著降低大鼠脑内淀粉样多肽的水平。 细胞培养系统(见附录1)。这一应用的长期目标是阐明生物利用度 白藜芦醇及其代谢物在啮齿动物体内的代谢及其体外抗淀粉样蛋白生成特性的研究 并在体内作为鉴定新的互补和替代的必要前提 用于预防与阿尔茨海默病相关的神经退化机制的药物。

Concordant epidemiological studies have demonstrated that moderate consumption of wine reduces the risk of developing Alzheimer's disease. Several antioxidant polyphenols occur in abundance in wine and are suspected to contribute to the beneficial effect of wine consumption in Alzheimer's disease. Despite skepticism concerning the bioavailability of these polyphenols, recent in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases, and consequently, a safety-efficacy study in Alzheimer's disease patients treated with resveratrol is currently conducted at the Mount Sinai School of Medicine. However, the exact molecular mechanisms involved in the beneficial properties of resveratrol and other natural polyphenols on the neurodegenerative process in Alzheimer's disease brain, remain to be clearly defined. Our recent data have revealed that resveratrol (frans-3,4',5-trihydroxystilbene) markedly lowers the levels of amyloid-p peptides in cell culture systems (see appendix 1). The long-term goal of this application is to elucidate the bioavailability of resveratrol and its metabolites in rodents and to characterize their anti-amyloidogenic properties in vitro and in vivo as a necessary prerequisite to the identification of novel complementary and alternative medicines for the prevention of the neurodegenerative mechanisms associated with Alzheimer's disease.