Glia and the progression of Parkinson's disease: Bystanders or villains?

帕金森病(PD)是一种慢性进行性神经退行性疾病，没有治愈方法或有效的治疗方法。我们知道帕金森病在大脑中从哪里开始，但它是如何扩散到影响越来越多的细胞还不清楚。这种缺乏理解一直是治疗发展的障碍。在这个项目中，我们将使用新的模型，这些模型将使我们能够前所未有地深入了解疾病传播的过程，并在这样做的过程中揭示治疗开发的新目标。

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with no cures or effective treatments. We know where in the brain PD begins but how it spreads to affect more and more cells is unknown. This lack of understanding has been a barrier to treatment development. In this project we will use new models that will enable unprecedented insight into this process of disease spreading, and in doing so will reveal new targets for therapeutic development.