CPEA Data Coordinating Center

描述(由申请人提供)：自1997年以来，国家儿童健康和人类发展研究所(NICHD)和国家耳聋和其他沟通障碍研究所(NIDCD)为自闭症神经生物学和遗传学网络：自闭症卓越合作计划(CPEA)提供了资金。由10个多学科项目组成的CPEA网络将再延长5年，以继续研究自闭症的基因、大脑结构、大脑功能和行为以及临床病程。三个不同的实体(DMSTAT公司、波士顿大学文理学院统计和咨询股和波士顿大学公共卫生学院生物统计系)成立了一个小组--DMSTAT/BU，提议与CPEA网络合作，并作为其中央数据协调中心。我们由生物统计学家、流行病学家、统计遗传学家、项目经理、程序员和数据经理组成的多学科团队可以有效和高效地满足CPEA网络持续不断和不断变化的需求。 DMSTAT/BU的主要目标是向CPEA项目的所有工作人员提供综合支助 前沿：1)一致、高效、成本效益高和高质量的数据管理，以及2)在研究设计、随机方案、匹配程序、统计遗传学和多变量分析方面的生物统计学专业知识。DMSTAT/BU将在以下领域协助项目工作人员：研究设计和方案制定、简化数据收集和提高数据质量的创新程序、行政管理、工作人员培训、研究监测、法规遵从性、统计设计、分析和报告以及研究文件，此外，DMSTAT/BU还将应用我们行之有效的数据管理和统计分析程序，为网络开发一个网站，作为研究基础设施的骨干。该网站将有管理(例如，电子邮件链接、会议信息、人员联系信息、项目文件、费用跟踪)和数据收集(分布式跟踪和数据输入系统)部分。网站中的报告模块将使CPEA网络的授权成员能够获得所有行政和数据管理信息。 我们组建的团队具有必要的经验，可以有效地满足 CPEA网络。使我们有别于竞争对手的特质是：在精简和组织流程方面的创新，我们教育各级研究人员并与之沟通的能力，我们分析和统计知识的广度和深度，我们在数据管理的所有方面对诚信的承诺，以及我们在类似规模和范围的研究方面的出色记录。

DESCRIPTION (provided by applicant): Since 1997, the National Institute of Child Health and Human Development (NICHD) and the National Institute on Deafness and Other Communication Disorders (NIDCD) has provided funding for a Network on the Neurobiology and Genetics of Autism: Collaborative Programs of Excellence in Autism (CPEA). The CPEA network of 10 multidisciplinary projects is being extended for an additional five years to continue studies of genes, brain structure, brain function and behavior and the clinical course of autism. Three separate entities (DMSTAT, Inc., the Boston University Statistics and Consulting Unit at the College of Arts and Sciences and the Department of Biostatistics at the Boston University School of Public Health) have formed a group, DMSTAT/BU, proposing to collaborate with the CPEA network and to serve as its centralized data coordinating center (DCC). Our multi-disciplinary team of biostatisticians, epidemiologists, statistical geneticists, project managers, programmers and data managers can effectively and efficiently serve the ongoing and changing needs of the CPEA network. The primary goal of DMSTAT/BU is to provide integrated support to all CPEA project staff on two fronts: 1) consistent, efficient, cost-effective and high quality data management, and 2) biostatistical expertise in study design, randomization schemes, matching procedures, statistical genetics and multivariable analysis. DMSTAT/BU will assist project staff in the following areas: study design and protocol development, innovative processes to streamline data collection and increase data quality, administrative management, staff training, study monitoring, regulatory compliance, statistical design, analysis and reporting, and study documentation, in addition to applying our proven data management and statistical analysis procedures, DMSTAT/BU will develop a website for the network which will serve as the backbone of the study infrastructure. The website will have administrative (e.g., e-mail links, meeting information, personnel contact information, project documentation, expense tracking) and data collection (distributed tracking and data entry systems) components. A reporting module in the website will make all of the administrative and data management information accessible to authorized members of the CPEA network. The team we have assembled has the requisite experience to effectively serve the needs of the CPEA network. The qualities that set us apart from our competitors are: innovation in streamlining and organizing processes, our abilities to educate and communicate with study staff at all levels, the breadth and depth of our analytic and statistical knowledge, our commitment to integrity in all aspects of data management, and our outstanding track record on studies of similar size and scope.