High Risk Drug Use & HIV-Learning from the NYC Epidemic

描述(由申请人提供)： 这项申请是为了与P30核心中心、药物使用和艾滋病毒研究中心(CDUHR)竞争的延续。提议继续进行，因为(A)艾滋病毒研究的进展使人们越来越重视社会层面的影响，以帮助了解艾滋病毒的危险行为和传播；(B)CDUHR的项目提供了一套独特的研究，通过这些研究，可以在多学科环境中审查和整合对艾滋病毒的一系列社会层面的影响。此外，对核心中心的需求有所增加：虽然启动母方赠款是为了向9个与艾滋病毒和毒品使用有关的项目提供支助，但这一延续将为23个项目提供研究基础设施。总体科学目标将是加强关于社会层面对艾滋病毒相关危险行为的影响、预防和在吸毒者中传播艾滋病毒的知识。CDUHR将提供支持，以提高调查人员的生产力，促进项目运作的效率，并加强协作和协同作用，以便出现新的研究问题和研究，这些问题和研究将超过通过简单总结个别项目的活动所能取得的成就。此外，CDUHR将支持开发新的知识、理论和方法，并将其传播到实地。CDUHR的目标将通过6个核心实现：(1)社会理论核心--促进超个人理论的使用和发展；(2)研究方法核心--加强使用新出现的社会层面的研究方法；(3)统计和数据分析核心--促进使用适用于群体和多层次分析的统计方法；(4)战略比较核心--促进和开展以流行病为分析单位的研究；(5)传播和培训核心--维护和提高工作人员的知识和技能，并向服务提供者传播研究结果；和(6)管理核心--提供科学的领导，并确保跨核心的集成以及跨项目和调查人员的协同。

DESCRIPTION (provided by applicant): This application is for a competing continuation of a P30 Core Center, the Center for Drug Use and HIV Research (CDUHR). A continuation is proposed because (a) advancement in HIV research has led to an increasing focus on social-level influences to help understand HIV risk behaviors and transmission, and (b) the projects that comprise CDUHR provide a unique set of studies through which a range of social-level influences on HIV can be examined and integrated in a multidisciplinary environment. In addition, the need for a Core Center has increased: whereas the parent grant was initiated to provide support to 9 projects related to HIV and drug use, this continuation will provide a research infrastructure for 23 projects. The overarching scientific aim will be to enhance knowledge regarding social-level influences on HIV-related risk behaviors, prevention and transmission of HIV among drug users. CDUHR will provide support to increase the productivity of investigators, foster efficiency in project functioning, and enhance collaboration and synergy so that new research questions and studies will emerge which will exceed the accomplishments achievable by the simple summation of the activities of the individual projects. In addition, CDUHR will support the development of new knowledge, theory and methods and their dissemination to the field. The aims of CDUHR will be accomplished through 6 cores: (1) Social Theory Core -- furthers the use and development of supra-individual theory; (2) Research Methods Core -- enhances use of newly-emerging social-level research methods; (3) Statistics and Data Analysis Core fosters use of statistical methods that are appropriate for group and multi-level analyses; (4) Strategic Comparisons Core -- facilitates and undertakes studies with epidemics as the unit of analysis; (5) Dissemination and Training Core -- serves to maintain and advance knowledge and skills of staff and disseminate findings to service providers; and (6) Administration Core -- provides scientific leadership and ensures integration across Cores and synergy across projects and investigators.