Clinical Oncology Program Biostatistical Center

美国癌症协会估计，2005年有超过350，000例新的乳腺癌病例或 结直肠癌和近100，000例与这些癌症相关的死亡，这是一个重大的公共卫生问题。 这个问题仍然是国家外科辅助乳腺和肠道项目（NSABP）的焦点。有关详细 40多年来，NSABP成功地进行了大规模的随机临床试验， 结肠直肠癌，旨在提高护理标准，生活质量和生存的人， 发展这些疾病。1992年，NSABP开始实施乳腺癌预防方案。2002-2003年， NSABP占64%的乳腺癌患者和78%的结直肠癌患者， 进入了NCI III期临床试验，这些试验可用于这些患者。超过三分之一的患者 由CCOP研究者入组。自1984年NSABP成为CCOP研究基地以来， CCOP研究人员已经统计了超过21，600名治疗试验患者和超过33，100名 参与者已参加BCPT和星星乳腺癌预防试验。的及时性和 通过这些方案获得的数据质量非常好，并对以下方面作出了积极贡献： 国家生物多样性战略计划数据的整体完整性，并大大加强了关于生物多样性的科学信息基础。 在建议的计划期间，我们会继续进行有关的工作， 作为支持NSABP CCOP治疗、癌症控制和预防的数据和统计中心 科学议程。在这方面，我们将继续加强利用更新的数据技术 收集、数据管理以及临床研究中心合作者的沟通和培训，目标是 开发更有效的方法来设计、实施和分析临床试验。本研究 一项提案要求提供资金，以使气候公约缔约方会议、气候公约缔约方会议和预防气候变化委员会能够继续运作， NSABP生物统计中心的组成部分，提供：1）数据管理支持， 收集和处理NSABP试验的数据; 2）质量保证计划，确保 收集的数据具有最高的完整性; 3）在NSABP研究的发展中进行科学合作 为开展研究提供议程和后勤支持;以及4）统计领导和支持 试验和相关研究的设计、监测和分析。

The American Cancer Society estimates that in 2005 there were more than 350,000 new cases of breast or colorectal cancers and almost 100,000 deaths related to these cancers, This is a substantial public health problem that remains the focus the National Surgical Adjuvant Breast and Bowel Project (NSABP). For more than 40 years, the NSABP has successfully conducted large-scale, randomized clinical trials in breast and colorectal cancer designed to improve the standard of care, quality of life and survival of persons who develop these diseases. In 1992, the NSABP began a breast cancer prevention program. In 2002-2003, the NSABP accounted for 64% of the breast cancer patients and 78% of the colorectal cancer patients who entered the NCI Phase III trials that were available for these patients. More than one-third of these patients were enrolled by CCOP investigators. Since 1984, when NSABP became a CCOP Research Base, the CCOP investigators have accounted for more than 21,600 treatment trial patients and more than 33,100 participants have been enrolled in the BCPT and STAR breast cancer prevention trials. The timeliness and quality of data obtained through these programs have been exceptional and have contributed positively to overall NSABP data integrity and substantially enhanced the base of scientific information regarding the treatment and prevention of cancer.ln the proposed project period, funding will be used to sustain our efforts as a data and statistical center in support of the NSABP CCOP treatment, cancer control and prevention scientific agenda. In that capacity, we will continue to enhance the utilization of newer technologies for data collection, data management and the communication and training of clinical site collaborators with the goal of developing more efficient methodologies to design, conduct and analyze clinical trials. This research proposal requests funding to enable the continued functioning of the CCOP, MB-CCOP and Prevention components of the NSABP Biostatistical Center which provide: 1) data management support for the collection and processing of data from NSABP trials; 2) quality assurance programs which ensure that the collected data is of the highest integrity; 3) scientific collaboration in the development of the NSABP research agenda and logistical support for the conduct of the research; and 4) statistical leadership and support for the design, monitoring and analysis of trials and correlative studies.