CORE--ANIMAL MODELS

老鼠模型已经成为越来越重要的工具，用于理解起源和 癌症的根本原因。小鼠基因组计划的完成表明，小鼠和人类的基因组差异不到1%。由于小鼠是一种定义明确的遗传模型，能够进行高通量表型评估，因此通过基因工程创造新的小鼠的能力为开发独特的癌症模型提供了机会。 动物模型共享资源的目的是为所有参与MCCC的研究人员提供必要的基础设施，以产生和分发用于癌症研究的转基因小鼠。梅奥诊所斯科茨代尔在培育转基因小鼠方面有着出色的记录，并将提供转基因服务，而梅奥诊所罗切斯特已经培育了大量基因敲除小鼠，并将提供基因敲除服务。自1999年以来，已有14个MCCC成员使用了这些资源，占所提供服务总数的39%。对这两个鼠标资源进行了组织，以便调查人员可以轻松获得所提供的所有服务，无论他们从哪个梅奥诊所网站进行研究。

Mouse models have become increasingly important tools used to understand the origins and underlying causes of cancer. The completion of the mouse genome project has demonstrated that there is less than 1% difference in the genomes between mice and humans. As the mouse is a well-defined genetic model capable of high throughput phenotypic assessment, the ability to create novel mice through genetic engineering provides the opportunity for the development of unique cancer models. The purpose of the Animal Models Shared Resource is to provide the infrastructure necessary to generate and distribute genetically modified mice for cancer research to all participating MCCC investigators. Mayo Clinic Scottsdale has an outstanding track record in generating transgenic mice and will provide transgene services, while Mayo Clinic Rochester has generated a multitude of gene knockout mice and will provide the gene "knockout" services. Since 1999 14 MCCC members have utilized these resources representing 39% of the total services provided. The two mouse resources have been organized such that investigators have easy access to all services provided irrespective of the Mayo Clinic site from which they conduct their research.