CORE Fb

脂质合成和生物物理表征核心（核心F）将服务于LIPID MAPS联盟 通过为每个脂质组学核心提供合成化学支持的所有方面， 生物物理表征支持所有脂质的利益财团。 脂质标准品和生产化学单位，由Avanti Polar Lipids，Inc.代表。将提供 参与联合体的研究者使用的脂质标准品。Avanti将合成一种 脂质库用作分析标准品以及提供用于生物测定的材料。小说 由Avanti提供给财团的脂质将提供给一般科学界， 脂质组学研究的好处 新型脂质合成设计部门将为所有新型脂质提供合成化学支持， 由财团发现的脂质中间体。该股将与Avanti Polar Lipids，Inc.密切合作。为 转让技术，使该财团发现的新型脂质的生产规模合成成为可能。 该单位还将与结构脂质组学和其他脂质核心（核心K）密切合作， 化学支持，以协助结构解析工作。 生物物理表征股将使用完善的方法，包括量热法和X射线 衍射，研究由Lipidomics Cores发现的新型脂质的生物物理特性。这 研究组还将研究脂多糖（LPS）与生物膜和模型的相互作用 巨噬细胞膜，以支持LIPID MAPS联盟。

The Lipid Synthesis and Biophysical Characterization Core (Core F) will serve the LIPID MAPS Consortium by providing all aspects of synthetic chemistry support for each of the Lipidomics Cores as well as biophysical characterization support for all lipids of interest to the consortium. The Lipid Standards and Production Chemistry Unit, represented by Avanti Polar Lipids, Inc. will provide lipid standards to be used by investigators participating in the consortium. Avanti will synthesize a library of lipids for use as analytical standards as well as provide materials for biological assays. Novel lipids provided to the consortium by Avanti will be made available to the general scientific community for the benefit of lipidomic research. The Novel Lipid Synthetic Design Unit will provide synthetic chemistry support for all new lipids and lipid intermediates discovered by the consortium. The Unit will work close with Avanti Polar Lipids, Inc. for the transfer of technology to enable production-scale synthesis of novel lipids discovered by the consortium. This unit will also work closely with the Structural Lipidomics and Other Lipids Core (Core K) to provide chemistry support to assist structure elucidation efforts. The Biophysical Characterization Unit will use well-established methods, including calorimetry and xray diffraction, to study the biophysical properties of novel lipids discovered by the Lipidomics Cores. This group will also study the interaction of lipopolysaccharide (LPS) with biological membranes and model macrophage membranes in support of the LIPID MAPS Consortium.