DBT-ACES: Evaluation of Feasibility

描述（由申请人提供）：DBT-接受退出系统的挑战（DBT- aces） DBT的高年级是专门为患有严重边缘型人格障碍的精神残疾人士设计的，以帮助他们实现总统新自由精神健康委员会建议的康复。在前后评价中显示，DBT-ACES可以增加就业和自给自足。这项R34治疗发展研究进一步评估了DBT-ACES的可行性和可接受性，以及未来可能进行疗效试验的随机对照试验研究程序。它有三个具体目标：(1)进一步完善DBT-ACES手册，包括其可行性和治疗保真度；(2)从招募、减量、评估和照常治疗（TAU）控制条件等方面，制定DBT-ACES疗效试验的方法并评估其可行性；(3)开展DBT-ACES （n=15）与TAU （n=15）的小型随机临床试验先导研究，评估DBT-ACES和TAU的损耗率，以及研究治疗对主要和次要措施的实验效果的统计学可行性。由于DBT- aces是一种先进的DBT治疗，研究参与者将接受标准DBT（由县公共精神卫生基金支付），然后那些稳定且对就业感兴趣的人将随机分配到DBT- aces或TAU进行第二年的治疗。

DESCRIPTION (provided by applicant): The DBT-Accepting the Challenges of Exiting the System (DBT-ACES) advanced year of DBT has been designed specifically for psychiatrically disabled individuals with severe borderline personality disorder to assist them to achieve recovery as recommended in the President's New Freedom Commission on Mental Health. DBT-ACES has been shown in pre-post evaluation to increase both employment and self-sufficiency. This R34 treatment development study further evaluates the feasibility and acceptability of DBT-ACES and of the randomized controlled trial study procedures for a possible future efficacy trial. It has three specific aims: (1) to further develop the DBT-ACES manual including its feasibility and treatment fidelity, (2) to develop the means for and evaluate the feasibility of an efficacy trial of DBT-ACES in terms of recruitment, attrition, assessment, and a treatment-as-usual (TAU) control condition, and (3) to conduct a small randomized clinical trial pilot study of DBT-ACES (n=15) vs. TAU (n=15) which will evaluate attrition rates for DBT-ACES and TAU and the statistical feasibility of studying experimental effects of the treatments on primary and secondary measures. Because DBT-ACES is an advanced DBT treatment, study participants will all receive standard DBT (paid for by county public mental health funds) and then those who are stable and interested in employment will be randomized to DBT-ACES or TAU for a second year of treatment.