SEARCH for Diabetes in Youth 2: South Carolina Center

这项建议建立在一个为期五年的研究项目--青年糖尿病研究项目--的标准化数据基础上 收集工作，经验丰富的调查团队，建立的案件查明基础设施，以及种族 人口基础多样化。这是一个来自六个搜索临床站点的常见的集成应用程序，其中 继续并扩大搜索所开展的工作，以解决以下具体问题 研究目标：目标1：前瞻性确定新诊断(2006-2009年)年龄以下的事件病例 20年，以估计青年糖尿病发病率的时间趋势； 目标2：对2002-2005年已招募进行搜索的事件案件进行纵向跟踪，按顺序 根据临床和生化因素记录新诊断的糖尿病的演变； 目标3：在SEARCH的头五年开始进行全面分析，并扩大护理质量的范围 评估，以涵盖更广泛定义的质量概念和衡量标准； 目标4：制定和验证青年糖尿病类型的简单和低成本病例定义和分类 可用于公共卫生监测。 这项提议的新颖性包括它的综合性，它将主要和及时的方面结合在一起 儿童糖尿病研究：一项流行病学研究，在美国是独一无二的，关于儿童糖尿病的时间趋势 青年糖尿病发病率；青年糖尿病自然病史的病理生理学成分；a 对护理过程和生活质量的研究；以及从公共卫生角度对#年糖尿病的病例分类 青春年华。这项研究对公共卫生至关重要，因为它将提供关于是否和 在美国不同种族/民族的年轻人中DM增加了多少，关于如何 糖尿病对身体健康的影响，包括并发症，以及关于糖尿病质量的宝贵数据 这些年轻人的关怀和生活质量。南卡罗来纳州诊所的独特优势包括： 1)调查人员在国家科学领导方面的丰富经验，包括在搜索方面的领导 出版物和搜索辅助研究；2)高度稳定和经验丰富的本地搜索诊所工作人员，以 确保搜索项目的有效运作；以及3)成功识别和纳入非洲人 美国青年，包括许多生活在医疗服务不足的社区的人。

This proposal builds upon a five year research project, SEARCHfor Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which Droposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM accordingto clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCHand expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth. The particular strengths of the South Carolina clinical site include: 1) extensive experience of the investigators in national scientific leadership including leadership in SEARCH publications and SEARCH ancillary studies; 2) a highly stable and experienced local SEARCH clinic staff to ensure efficient operation of the SEARCH project; and 3) success in identification and inclusion of African American youth, including many living in medically underserved communities.