Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study

继续进行青少年糖尿病研究 (UC4) 青少年糖尿病研究的有限竞争

• 批准号: 9343335
• 负责人: Ralph B. DAgostino
• 金额: $ 79.76万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9343335
• 关键词: 20 year old; Acute; Address; Adult; Affect; African American; Age; American Indians; Ancillary Study; Asians; Behavioral; Biological; Blood Pressure; Blood Vessels; Cardiac; Caring; Cause of Death; Child; Childhood; Chronic; Clinical; Cohort Studies; Complications of Diabetes Mellitus; Continuity of Patient Care; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis; Employment; Epidemiologic Studies; Ethnic Origin; Ethnic group; Foundations; Frequencies; Health; Health Insurance; Healthcare; Healthcare Systems; High Prevalence; Hispanics; Hypoglycemia; Incidence; Individual; Inflammatory; Insulin-Dependent Diabetes Mellitus; Intervention; Kidney Diseases; Laboratories; Life; Life Expectancy; Marriage; Measures; Mental Depression; Metabolic; Minority; Morbidity - disease rate; National Health Policy; Nephrology; Neurocognitive; Neuropathy; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Outcome; Pacific Island Americans; Participant; Pathway interactions; Patients; Pattern; Peripheral Nervous System Diseases; Persons; Prevalence; Process; Provider; Public Health; Quality of Care; Quality of life; Race; Recruitment Activity; Registries; Retinal Diseases; Risk; Risk Factors; Schools; Series; Social support; Specimen; Surveys; Technology; Time; Visit; Work; Youth; arterial stiffness; cohort; cost; design; early onset; education financing; emerging adult; ethnic minority population; follow-up; foot; mortality; non-diabetic; population based; racial and ethnic; repository; response; screening; sex; social; socioeconomics; stressor; type I and type II diabetes; young adult

 DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, large, culturally diverse, multi-center and population-based epidemiological study of youth with diabetes. Initiated in 2000 and encompassing the major racial/ethnic groups in the U.S: non-Hispanic white, African-American, Hispanic, Asian-Pacific Islander, and American Indian, SEARCH was designed to estimate the prevalence, incidence and clinical presentation of diabetes in youth age < 20 years, by age, sex, race/ethnicity and diabetes type (SEARCH Registry Study). Beginning in 2002, SEARCH recruited a series of incident cohorts representative of the diverse racial/ethnic, socioeconomic and geographic base population, who were well-characterized through a variety of surveys, physical and laboratory assessments soon after diagnosis and followed them longitudinally (SEARCH Cohort Study). This proposal will continue longitudinal follow-up of the participants in the SEARCH Cohort Study to examine four Specific Aims: 1) To establish, compare and contrast the burden (prevalence, incidence, progression and clustering) of acute and chronic complications of diabetes, and explore the responsible risk factors and pathways among youth and young adults with type 1 and type 2 diabetes, 2) To explore, compare and contrast processes of care (including barriers to care and quality of care) and their influence on quality of life among youth with type 1 and type 2 diabetes, as they transition from pediatric to adult care, 3) to conduct surveillance of mortality including cause of death in the SEARCH cohort, and 4) to maintain, supplement and promote access to the SEARCH Cohort repository for biological specimens to conduct scientifically and logistically appropriate ancillary studies. Since there is an earlier onset and increasing rate of both type 1 and type 2 diabetes, the already high burden of diabetes to the individual and the nation will increase over time. Understanding the factors and pathways that contribute to this burden will provide the foundation to develop strategic interventions to limit individual morbidity and mortality and promote an effective, sustainable national health policy.

 描述（由申请人提供）：青年糖尿病研究是一项正在进行的、大型的、文化多样性的、多中心的、以人群为基础的青年糖尿病流行病学研究。该研究于2000年启动，涵盖了美国的主要种族/民族群体：非西班牙裔白色、非洲裔美国人、西班牙裔、亚太岛民和美洲印第安人，旨在按年龄、性别、种族/民族和糖尿病类型估计20岁以下青年糖尿病的患病率、发病率和临床表现（ESTA登记研究）。从2002年开始，研究人员招募了一系列代表不同种族/民族、社会经济和地理基础人群的事件队列，这些人群在诊断后不久通过各种调查、身体和实验室评估进行了充分表征，并对他们进行了纵向跟踪（研究队列研究）。本提案将继续对研究队列研究的参与者进行纵向随访，以检查四个具体目标：1）确定、比较和对比负担（患病率、发病率、进展和聚集性），并探索青年和年轻成人1型和2型糖尿病患者中负责的风险因素和途径，2）探索，比较和对比护理过程（包括护理障碍和护理质量）及其对1型和2型糖尿病青年患者生活质量的影响，因为他们从儿科过渡到成人护理，3）对死亡率进行监测，包括死亡原因，以及4）保持，补充和促进对生物样本的研究和研究组群储存库的访问，以进行科学和后勤上适当的辅助研究。由于1型和2型糖尿病的发病较早且发病率不断增加，糖尿病对个人和国家已经很高的负担将随着时间的推移而增加。了解造成这一负担的因素和途径将为制定战略干预措施以限制个体发病率提供基础 和死亡率，并促进有效、可持续的国家卫生政策。

项目成果

Response to Comment on Jaiswal et al. Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study. Diabetes Care 2017;40:1226-1232.

对 Jaiswal 等人的评论的回应

• DOI: 10.2337/dci17-0058
• 发表时间: 2018
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Jaiswal,Mamta;Divers,Jasmin;Pop-Busui,Rodica;Feldman,EvaL
• 通讯作者: Feldman,EvaL

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012.

• DOI: 10.1056/nejmoa1610187
• 发表时间: 2017-04-13
• 期刊: The New England journal of medicine
• 作者: Mayer-Davis EJ;Lawrence JM;Dabelea D;Divers J;Isom S;Dolan L;Imperatore G;Linder B;Marcovina S;Pettitt DJ;Pihoker C;Saydah S;Wagenknecht L;SEARCH for Diabetes in Youth Study
• 通讯作者: SEARCH for Diabetes in Youth Study