Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study

 描述(由申请人提供)：寻找青年糖尿病(SEARCH)是一个正在进行的、大型的、多元文化的、多中心的、以人群为基础的青年糖尿病流行病学研究。Search成立于2000年，涵盖了美国主要的种族/民族群体：非西班牙裔白人、非裔美国人、西班牙裔、亚太岛民和美国印第安人，旨在按年龄、性别、种族/民族和糖尿病类型估计20岁青年糖尿病的患病率、发病率和临床表现(搜索登记研究)。从2002年开始，Search招募了一系列事件队列，代表不同的种族/族裔、社会经济和地理基础人口，他们在确诊后不久通过各种调查、身体和实验室评估得到了很好的特征，并对他们进行了纵向跟踪(Search Cohort Study)。这项建议将继续对Search队列研究的参与者进行纵向跟踪，以检查四个具体目标：1)建立、比较和对比糖尿病急性和慢性并发症的负担(患病率、发病率、进展和聚集)，并探索1型和2型糖尿病青年中负责任的风险因素和途径；2)探索、比较和对比1型和2型糖尿病青年从儿科护理过渡到成人护理的护理过程(包括护理障碍和护理质量)及其对生活质量的影响，3)监测搜索队列中的死亡率，包括死亡原因；以及4)维持、补充和促进生物标本搜索队列储存库的使用，以进行科学和后勤上适当的辅助研究。由于1型和2型糖尿病发病较早，发病率也在增加，糖尿病给个人和国家带来的沉重负担将随着时间的推移而增加。了解造成这一负担的因素和途径将为制定战略性干预措施以限制个人发病率提供基础。 并促进一项有效、可持续的国家卫生政策。

 DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, large, culturally diverse, multi-center and population-based epidemiological study of youth with diabetes. Initiated in 2000 and encompassing the major racial/ethnic groups in the U.S: non-Hispanic white, African-American, Hispanic, Asian-Pacific Islander, and American Indian, SEARCH was designed to estimate the prevalence, incidence and clinical presentation of diabetes in youth age < 20 years, by age, sex, race/ethnicity and diabetes type (SEARCH Registry Study). Beginning in 2002, SEARCH recruited a series of incident cohorts representative of the diverse racial/ethnic, socioeconomic and geographic base population, who were well-characterized through a variety of surveys, physical and laboratory assessments soon after diagnosis and followed them longitudinally (SEARCH Cohort Study). This proposal will continue longitudinal follow-up of the participants in the SEARCH Cohort Study to examine four Specific Aims: 1) To establish, compare and contrast the burden (prevalence, incidence, progression and clustering) of acute and chronic complications of diabetes, and explore the responsible risk factors and pathways among youth and young adults with type 1 and type 2 diabetes, 2) To explore, compare and contrast processes of care (including barriers to care and quality of care) and their influence on quality of life among youth with type 1 and type 2 diabetes, as they transition from pediatric to adult care, 3) to conduct surveillance of mortality including cause of death in the SEARCH cohort, and 4) to maintain, supplement and promote access to the SEARCH Cohort repository for biological specimens to conduct scientifically and logistically appropriate ancillary studies. Since there is an earlier onset and increasing rate of both type 1 and type 2 diabetes, the already high burden of diabetes to the individual and the nation will increase over time. Understanding the factors and pathways that contribute to this burden will provide the foundation to develop strategic interventions to limit individual morbidity and mortality and promote an effective, sustainable national health policy.