Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study

继续进行青少年糖尿病研究 (UC4) 青少年糖尿病研究的有限竞争

• 批准号: 9343335
• 负责人: Ralph B. DAgostino
• 金额: $ 79.76万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9343335
• 关键词: 20 year old; Acute; Address; Adult; Affect; African American; Age; American Indians; Ancillary Study; Asians; Behavioral; Biological; Blood Pressure; Blood Vessels; Cardiac; Caring; Cause of Death; Child; Childhood; Chronic; Clinical; Cohort Studies; Complications of Diabetes Mellitus; Continuity of Patient Care; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis; Employment; Epidemiologic Studies; Ethnic Origin; Ethnic group; Foundations; Frequencies; Health; Health Insurance; Healthcare; Healthcare Systems; High Prevalence; Hispanics; Hypoglycemia; Incidence; Individual; Inflammatory; Insulin-Dependent Diabetes Mellitus; Intervention; Kidney Diseases; Laboratories; Life; Life Expectancy; Marriage; Measures; Mental Depression; Metabolic; Minority; Morbidity - disease rate; National Health Policy; Nephrology; Neurocognitive; Neuropathy; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Outcome; Pacific Island Americans; Participant; Pathway interactions; Patients; Pattern; Peripheral Nervous System Diseases; Persons; Prevalence; Process; Provider; Public Health; Quality of Care; Quality of life; Race; Recruitment Activity; Registries; Retinal Diseases; Risk; Risk Factors; Schools; Series; Social support; Specimen; Surveys; Technology; Time; Visit; Work; Youth; arterial stiffness; cohort; cost; design; early onset; education financing; emerging adult; ethnic minority population; follow-up; foot; mortality; non-diabetic; population based; racial and ethnic; repository; response; screening; sex; social; socioeconomics; stressor; type I and type II diabetes; young adult

 DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, large, culturally diverse, multi-center and population-based epidemiological study of youth with diabetes. Initiated in 2000 and encompassing the major racial/ethnic groups in the U.S: non-Hispanic white, African-American, Hispanic, Asian-Pacific Islander, and American Indian, SEARCH was designed to estimate the prevalence, incidence and clinical presentation of diabetes in youth age < 20 years, by age, sex, race/ethnicity and diabetes type (SEARCH Registry Study). Beginning in 2002, SEARCH recruited a series of incident cohorts representative of the diverse racial/ethnic, socioeconomic and geographic base population, who were well-characterized through a variety of surveys, physical and laboratory assessments soon after diagnosis and followed them longitudinally (SEARCH Cohort Study). This proposal will continue longitudinal follow-up of the participants in the SEARCH Cohort Study to examine four Specific Aims: 1) To establish, compare and contrast the burden (prevalence, incidence, progression and clustering) of acute and chronic complications of diabetes, and explore the responsible risk factors and pathways among youth and young adults with type 1 and type 2 diabetes, 2) To explore, compare and contrast processes of care (including barriers to care and quality of care) and their influence on quality of life among youth with type 1 and type 2 diabetes, as they transition from pediatric to adult care, 3) to conduct surveillance of mortality including cause of death in the SEARCH cohort, and 4) to maintain, supplement and promote access to the SEARCH Cohort repository for biological specimens to conduct scientifically and logistically appropriate ancillary studies. Since there is an earlier onset and increasing rate of both type 1 and type 2 diabetes, the already high burden of diabetes to the individual and the nation will increase over time. Understanding the factors and pathways that contribute to this burden will provide the foundation to develop strategic interventions to limit individual morbidity and mortality and promote an effective, sustainable national health policy.

 描述（由适用提供）：在青年中寻找糖尿病（搜索）是一项持续的，大型，文化多样，多中心和基于人群的糖尿病青年流行病学研究。始于2000年，并涵盖了美国的主要种族/族裔群体：非西班牙裔白人，非洲裔美国人，西班牙裔，西班牙裔，亚洲太平洋岛民和美洲印第安人，旨在估算年龄<20岁的糖尿病的流行，事件和临床呈现，按年龄，性别，性别，种族群体和疾病，搜索和疾病，搜索型糖尿病（搜索）。从2002年开始，搜索招募了一系列代表多样性种族/族裔，社会经济和地理基础人口的事件，他们通过诊断后的各种调查，物理和实验室评估进行了良好的表现，并纵向遵循了这些评估（搜索队列研究）。 This proposal will continue longitudinal follow-up of the participants in the SEARCH Cohort Study to examine four Specific Aims: 1) To establish, compare and contrast the burn (prevalence, incident, progression and clustering) of acute and chronic complications of diabetes, and explore the responsible risk factors and pathways among youth and young adults with type 1 and type 2 diabetes, 2) To explore, compare and contrast processes of care (including barriers to care and护理质量）及其对1型和2型糖尿病青少年生活质量的影响，因为他们从小儿护理过渡到成人护理，3）进行死亡的监视，包括搜索队列中的死亡原因，以及4）维护，补充并促进搜索搜索同类库的访问，以进行生物学标本，以进行科学和逻辑上适当的辅助研究。由于1型和2型糖尿病的发作和增加的速度较早，因此糖尿病已经对个人和国家的燃烧率很高，随着时间的流逝。了解有助于这种燃烧的因素和途径将为制定战略干预措施以限制个人发病率 和死亡率并促进有效，可持续的国家卫生政策。

项目成果

Response to Comment on Jaiswal et al. Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study. Diabetes Care 2017;40:1226-1232.

对 Jaiswal 等人的评论的回应

• DOI: 10.2337/dci17-0058
• 发表时间: 2018
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Jaiswal,Mamta;Divers,Jasmin;Pop-Busui,Rodica;Feldman,EvaL
• 通讯作者: Feldman,EvaL

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012.

• DOI: 10.1056/nejmoa1610187
• 发表时间: 2017-04-13
• 期刊: The New England journal of medicine
• 作者: Mayer-Davis EJ;Lawrence JM;Dabelea D;Divers J;Isom S;Dolan L;Imperatore G;Linder B;Marcovina S;Pettitt DJ;Pihoker C;Saydah S;Wagenknecht L;SEARCH for Diabetes in Youth Study
• 通讯作者: SEARCH for Diabetes in Youth Study