New Investigation Initiatives for the Prevention of Complications of Thalassemia

描述(由申请人提供)：儿童纪念医院(CMH)地中海贫血综合计划致力于提供最先进的医疗服务，采用多学科方法，包括持续的血液警戒活动。地中海贫血患者是一个弱势群体，他们是儿童纪念医院和美国其他主要地中海贫血治疗中心最大的红细胞输注使用者群体。因此，他们仍然面临着已知的和潜在的血液传播病原体以及与输血治疗有关的其他并发症的高风险。这份申请将描述CMH对疾控中心正在进行的地中海贫血血液安全倡议的预期贡献，并将描述当前和拟议的活动，以加强医疗服务，促进预防和改善与疾病和/或输血相关的并发症的研究。作为美国中西部最大的地中海贫血治疗中心，儿童纪念医院的地中海贫血综合计划具有得天独厚的优势，可以为受这种疾病影响的日益多样化的种族和文化人群提供广泛的地理区域的专业知识。相关性：红细胞输注是治疗地中海贫血的基石，地中海贫血是一种严重的遗传性血液疾病。旨在改善血液安全监测的活动对广大公众的健康具有广泛的影响。这项申请中提出的项目旨在改善对血液传播感染、铁超载和其他与输血有关的并发症的监测。

DESCRIPTION (provided by applicant): The Comprehensive Thalassemia Program of the Children's Memorial Hospital (CMH) is committed to providing state-of the-art medical service services using a multidisciplinary approach, including ongoing hemo-vigilance activities. Patients with thalassemia are a vulnerable population who comprise the single largest group of red cell transfusion users at Children's Memorial Hospital and other major U.S. thalassemia treatment centers. As such, they remain at high risk from both known and potential blood-borne pathogens and other complications related to transfusion therapy. This application will delineate expected contributions of CMH to ongoing initiatives by the CDC on blood safety in thalassemia and will describe current and proposed activities to enhance medical services and facilitate research in the prevention and improved management of disease- and/or transfusion-related complications. As the largest thalassemia treatment center in the Midwestern United States, the Comprehensive Thalassemia Program of the Children's Memorial Hospital is uniquely positioned to provide expertise over a wide geographic area to an increasingly diverse ethnic and cultural population affected by this condition. Relevance: Red cell transfusions are a cornerstone for the management of thalassemia, a serious inherited blood disorder. Activities directed at improvements in blood safety monitoring have broad implication on the health of the general public. Projects proposed in this application are aimed at improvements in surveillance for blood borne infections, iron overload and other transfusion-related complications.