7th International Cerebral Vascular Biology Conference

描述(申请人提供)：本提案是为支持第七届国际脑血管生物学大会(CVB-2007)而提出的资金申请。脑血管生物学(CVB)会议是一年两次的会议，为从事中枢神经系统障碍和脑血管生物学研究的科学家和临床医生提供了一个广泛的国际讨论论坛。神经血管单位和血脑屏障已被美国国立卫生研究院确定为神经科学的优先研究领域。CVB-2007的任务是专门针对这些已确定的优先领域。主要目的是提高对脑屏障和神经血管单位的了解，并将这些知识转化为临床适用的策略，通过靶向血管病理进行脑部治疗和中枢神经系统疾病的管理。许多神经疾病和损害与突出的脑血管病变有关(例如，阿尔茨海默病的脑淀粉样血管病、中风的动脉粥样硬化等)。和/或增加血脑屏障通透性。它们包括：肿瘤、缺血、高血压、痴呆症、癫痫、感染、多发性硬化症和创伤。神经退行性变的机制理解方面的进展尚未找到临床翻译的成功途径。各种可能的治疗方法临床翻译的主要障碍是它们难以传递到受疾病影响的大脑或神经元。CVB会议的既定重点是健康和疾病中血-脑和血-脑脊液屏障的机制、调节和建模。CVB-2007的另一个关键重点将是转化性研究--跟踪从基本机制发现到临床前开发再到临床应用的路径。组织者的目标是增加临床医生的参与，包括神经科医生、神经外科医生和神经放射科医生。为了实现这一主要目标，会议的一个重要组成部分将致力于神经血管单位和中枢神经系统障碍在脑部疾病中的作用，并计划举行关于中风、阿尔茨海默病和神经炎症性疾病的具体会议。包括脑瘤和癫痫在内的其他病理问题也将在整个会议的不同会议中讨论。这些疾病的健康“负担”是巨大的--CVB-2007将有助于更好地了解神经系统疾病的血管成分，并有助于开发针对这些疾病的更有效的治疗方法。CVB-2007的主要目标是在脑血管研究领域的研究人员和临床医生之间交流关于科学发现、创新和技术发展的信息。这次会议的主要重点将是转化性研究--从基础机制发现到临床前开发再到临床应用。

DESCRIPTION (provided by applicant): This proposal is a request for funds toward support of the 7th International Cerebral Vascular Biology Conference (CVB-2007). The Cerebral Vascular Biology (CVB) Conferences are bi-annual meetings that provide a broad international discussion forum for scientists and clinicians engaged in research on CNS barriers and cerebral vascular biology. The neurovascular unit and blood brain barrier have been identified by NIH as priority research areas in neurosciences. CVB-2007 mission is to specifically 'target' these identified priority areas. The key objective is to improve the understanding of the brain barriers and the neurovascular unit and to translate this knowledge into clinically applicable strategies for brain therapeutic delivery and management of CNS diseases by targeting vascular pathologies. Many neurological disorders and lesions are associated with prominent cerebrovascular pathology (e.g., cerebral amyloid angiopathy in Alzheimer's disease, atherosclerosis in stroke, etc.) and/or increased BBB permeability. They include: neoplasia, ischemia, hypertension, dementia, epilepsy, infection, multiple sclerosis, and trauma. The advances in mechanistic understanding of neuronal degeneration have not found successful conduits for clinical translation. The major impediment for clinical translation of various potential treatments is difficulty in their delivery to the brain or neurons affected by disease. The established emphasis of CVB conferences is on mechanisms, modulation and modeling of blood-brain and blood-CSF barriers in health and disease. The key additional emphasis of the CVB-2007 will be on translational research - tracing the path from fundamental mechanistic discovery through pre-clinical development to clinical application. The objective of the organizers is to increase the participation of clinicians including neurologists, neurosurgeons, and neuroradiologists. To achieve this primary goal, a significant component of the meeting will be dedicated to the role of the neurovascular unit and CNS barriers in brain diseases with specific sessions planned on stroke, Alzheimer's disease and neuroinflammatory diseases. Other pathologies including brain tumors and epilepsy will also be covered in various sessions throughout the conference. The health 'burden' of these pathologies is immense - the CVB-2007 will contribute to better understanding of vascular component of neurological diseases and to development of more efficacious therapies that target these diseases. The primary objective of the CVB-2007 is to serve as a catalyst for exchange of information on scientific discoveries, innovation, and technology development among researchers and clinicians working in the cerebrovascular research field. The key accent of this meeting will be on translational research - advancing from fundamental mechanistic discoveries through pre-clinical development to clinical applications.