Risky Families Embedded in Risky Environments

这项申请要求五年的资金，以继续我们的努力，以了解因素， 艾滋病毒感染率、艾滋病毒危险行为和艾滋病发病率居高不下 在波多黎各的吸毒者中。总体研究目标是开发和测试评估 父母吸毒和抑郁的影响，青少年物质使用和精神病理学，以及 作为艾滋病毒的危险行为，以及文化，家庭/家庭外和个人的中介作用 从青春期早期到晚期的转变和转折点的因素。 吸毒（n-375）和不吸毒的父母（n-375）及其一个后代（n-750），13至15岁 年龄30岁，居住在贫困社区的研究参与者组成了一组。这 该申请提出了一项具有巢式乳房造影术的前瞻性研究设计。数据将由 多重评估策略：访谈协议和结构化精神病学访谈， 西班牙语版的儿童诊断性面谈时间表2.1版（DISC 2.1），以评估 青少年在基线和年份中物质使用/滥用、抑郁和行为障碍 2、3和4。西班牙文版的药物滥用和抑郁量表 国际诊断访谈（CIDI）将评估父母中的药物滥用和抑郁症 在基线和第2年和第3年。这些诊断数据，沿着每年对父母的采访， 课程将涵盖与参与者生活事件相关的重要和广泛的主题， 过渡;如学校和工作经验，药物和酒精使用/滥用，犯罪行为， 应对机制（例如，社会支持，自尊和掌握），和抑郁 这些数据和通过深入访谈收集的信息 我们的民族志小组将提供具体的信息， 青少年过渡，特别是药物使用/滥用和艾滋病毒风险行为以及适应 他们从青春期早期到晚期的预期角色。 地点（组织、城市、州） - 波多黎各，巴亚蒙，加勒比中央大学 关键人员。参见说明。根据需要使用续页，以下列格式提供所需信息。 从首席研究员开始。按字母顺序列出所有其他关键人员，姓在前。 名称组织在项目中的角色 拉法埃拉？罗伯斯河UniversidadCentral del Caribe首席研究员 波多黎各大学顾问 Clatts，Michael国家发展研究院顾问 Colon，Hector M.加勒比中央大学 Finlinson，H.Ann加勒比中部大学共同研究员 Garcia，Frances中加勒比大学顾问 见下一页。 披露许可声明。仅适用于SBIR/STTR。参见说明。0是0否 PHS 398（修订版05/01）第2页表格第2页 在整个应用程序的底部连续编号页面。不要使用诸如3a、3b之类的后缀。 说明，

This application requests five years of funding to continue our efforts to understand the factors that are sustaining the high prevalence of HIV infection, HIV risk behaviors and high incidenceof AIDS among Puerto Rican drug users. The overall study goal is to develop and test models that assess the effects of parental drug use and depression, adolescent substance use and psychopathology, as well as HIV risk behaviors, and the mediating effects of cultural, familial/ extra-familial and personal factors on transitions and turning points that define the movement from early to late adolescence. Drug using (n-375) and non-drug using parents (n-375) and one of their offspring (n-750), 13 to 15 years of age, residing in poor neighborhoods comprise the group of study participants. This application proposes a prospective study design with a nestedethnography. Data will be collected by multiple assessment strategies: interview protocols and structured psychiatric interviews usingthe Spanish version of the Diagnostic Interview Schedule for ChildrenVersion 2.1 (DISC 2.1) to assess substance use/ abuse, depression and conduct disorders among adolescents at baseline and in year 2, 3 and 4. The Spanish version of the substance abuse and depression scales of the Composite International Diagnostic Interview (CIDI) will assess substance abuse and depression among parents at baseline and inyear 2 and 3. These diagnostic data, along with annual interviews of parents and adolescentswill cover a critical and wide range of topics related to participants' life events and transitions; such as school and work experience, drug and alcohol use/ abuse, criminal behavior, coping mechanisms (e.g., social support, self-esteem and mastery), and depressive symptomatology.These data and the information collected through the in-depth interviews conducted by our ethnographic team will provide specific informationwith which to assess adolescent transitions, especially substance use/ abuse and HIV risk behaviors and adaptation to their expected roles as they move from early to late adolescence. PERFORMANCESITE(S) (organization, city, state) - Universidad Central del Caribe, Bayamon,Puerto Rico KEY PERSONNEL. See instructions. Use continuationpages as neededto provide the required information inthe format shown below. Start with Principal Investigator. List all other key personnelinalphabetical order, last namefirst. Name Organization Role on Project Robles, Rafaela R. UniversidadCentral del Caribe Principal Investigator Bernal, Guillermo University of Puerto Rico Consultant Clatts, Michael National Developmentand Research Institutes Consultant Colon, Hector M. Universidad Central del Caribe Co-investigator Finlinson,H.Ann UniversidadCentral del Caribe Co-Investigator Garcia, Frances Universidad Central del Caribe Consultant See next page. Disclosure Permission Statement. ADplicable to SBIR/STTR Onlv. See instructions. 0Yes 0No PHS398 (Rev. 05/01) Page2 Form Page 2 Number pagesconsecutively at the bottomthroughout the application. Donofusesuffixes such as 3a, 3b. Description,