Study of CWD Deer and Elk Prion Disease in Nonhuman Prim

这项研究旨在评估慢性消耗性疾病--鹿或麋鹿的一种普恩病毒疾病--可能会传播给人类的可能性。这一发现加剧了这一担忧，因为人类似乎容易感染一种牛普鲁恩病，即牛海绵状脑病(疯牛病)。为了研究CWD跨物种传播的可能性，用感染CWD的鹿或麋鹿的脑组织材料经口或脑内感染两种非人类灵长类动物松猴和食蟹猴。脑内感染的松鼠猴在感染三年后出现临床神经症状，并经脑部生化和病理检查证实患有普恩病毒病。对剩下的猴子的观察将至少再持续几年

This study is aimed at evaluating the potential that chronic wasting disease, a prion disease of deer or elk, might be transmissible to humans. This concern is amplified by the finding that humans appear to be susceptible to infection by a cattle prion disease, bovine spongiform encephalopathy (mad cow disase). To study the possibility of cross-species transmission of CWD, two species of nonhuman primates, squirrel monkeys and cynomologus macaques, were infected orally or intracerebrally with brain material derived from CWD affected deer or elk. Three years after infection intracerebrally infected squirrel monkeys developed clinical neurological signs and were confirmed by biochemical and pathological testing of brain to have a prion disease. Observations on the remaining monkeys will continue for at least a few more years