PK UNDER-STUDIED DRUGS IN PREGNANCY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在怀孕期间使用药物是很常见的。妊娠期慢性病未经治疗或治疗不当与母亲及其胎儿的发病率和死亡率显著相关。 女性在怀孕期间平均服用3种药物，不包括产前维生素。 对妊娠期间药物的药代动力学知之甚少。 我们所掌握的少量信息表明，妊娠期间发生的生理变化（肾滤过增加，CYP 3A，CYP 2D 6和CYP 2C 9活性增加以及CYP 1A 2活性降低）显著改变了妊娠期间身体处理药物的方式，因此改变了妊娠期间所需的药物剂量。 在大多数情况下，产科医生在怀孕期间根据药物在非怀孕个体中的处理方式以及他们的临床经验的额外影响来确定药物的剂量。 这项初步观察性研究的目的是评价孕妇在怀孕期间因治疗原因已经接受的药物的药代动力学，并将其与产后进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Medication use is very common during pregnancy. Untreated or inadequately treated chronic illness during pregnancy is associated with significant morbidity and mortality for both the mother and her fetus. On average, women take 3 medications during pregnancy, not counting prenatal vitamins. Very little is known about the pharmacokinetics of medications during pregnancy. The little information that we do have suggests that the physiologic changes that occur during pregnancy (increased renal filtration, increased activity of CYP3A, CYP2D6 and CYP2C9 and decreased activity of CYP1A2) significantly alter the way the body handles drugs during pregnancy and therefore changes the needed dosages of medications during pregnancy. In most cases, obstetricians base the dosage of medications during pregnancy on how the drugs are handled in non-pregnant individuals with the added influence of their clinical experience. The purpose of this pilot observational study is to evaluate the pharmacokinetics of medications that pregnant women are already receiving for therapeutic reasons during pregnancy and compare that to postpartum.