FIBROMYALGIA: CENTRAL FACTORS IN ITS ETIOPATHOGENESIS - SECOND CYCLE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的总体目标是测试10个假说，这些假说来自我们基于经验的纤维肌痛异常疼痛敏感性模型。本研究采用阶段性和紧张性热刺激，评价了个人相关的心理社会应激源(即应激性想象)对女性纤维肌痛(FM)患者和性别匹配的健康对照组疼痛反应的影响。这些反应包括：(A)疼痛和不适的VAS分级；(B)Xenon133单光子发射计算机断层扫描(SPECT)成像评估的局部脑血流量(RCBF)。所有参与者都是患有FM的右撇子女性患者和健康对照组，她们目前不符合DSM-IV轴I情感障碍的标准。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this investigation is to test 10 hypotheses derived from our empirically-based model of abnormal pain sensitivity in fibromyalgia (FM). The present study evaluates the effects of personally relevant, psychosocial stressors (i.e., stressful imagery) on the pain responses of female patients with fibromyalgia (FM) and sex-matched healthy controls using phasic and tonic thermal heat stimulation. These responses consist of stressor-evoked changes in (a) VAS ratings of pain and unpleasantness; and (b) regional cerebral blood flow (rCBF) assessed by Xenon133 single photon emission computerized tomographic (SPECT) imaging. All participants are right-handed female patients with FM and healthy controls who do not currently meet DSM-IV criteria for Axis I affective disorders.