SEX-RELATED DETERMINANTS OF PAIN RESPONSES IN FIBROMYALGIA-FAMILY STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this investigation is to better understand the consistent finding that first-degree relatives of women with fibromyalgia (FM) more frequently meet the ACR criteria for fibromyalgia and DSM-IV criteria for mood disorders than the first-degree relatives of healthy women without fibromyalgia or other disorders characterized by persistent pain. In order to achieve this aim, we propose to study (a) adult women who met ACR criteria for fibromyalgia (FM proband); (b) adult, healthy control women without FM or any other disorder characterized by persistent pain; and (c) one sibling of each FM proband and healthy control woman. We also propose to obtain three sets of data from the FM probands, healthy controls, and their siblings. These are data regarding (a) pain sensitivity in response to mechanical pressure stimulation, thermal heat stimulation, and ischemic (submaximun effort tourniquet) stimulation; (b) blood samples used to assay serum serotonin levels and produce genomic DNA samples; and (c) responses to a structured psychiatric interview (i.e., Diagnostic Interview Schedule) and standardized measures of psychosocial variables (e.g., Center for Epidemiological Studies-Depression scale; Kohn Reactivity Scale). We propose to use these data to test 7 hypotheses, derived from our model of the etiopathogenesis of FM, regarding the extent to which family history of FM is associated with enhanced pain sensitivity in a sex-dependent manner.