Untethered Mouse EEG Radio for Sleep

描述(申请人提供)：这个拟议的项目将开发一种小型无线设备，能够监测小鼠的脑活动(EEG)以及其他生理信号，如肌电和心电。目前，大脑活动是通过一根拴在老鼠和笼子顶部的电缆来监测的，这不允许自然活动，也不允许任何隧道或大多数其他典型的住房附件。尽管已经开发了新的无线设备，但它们的灵敏度不足以准确监测大脑活动。CleveMed已经开发了一种小型无线监测设备MousePaak(Tm)，这个拟议的项目将使MousePaak变得更小，因此对鼠标的干扰更小，从而允许更自然的活动，并增加新的自动化软件来提供睡眠分期信息。这种新的设备和软件在测试美国约4000万患有慢性或间歇性睡眠相关问题和障碍的人的新药物突破，以及测试其他药物突破可能对正常睡眠产生的影响方面，都将是非常宝贵的。拟议的项目将开发一种无线解决方案，用于监测小鼠在正常活动期间和睡眠时的大脑和肌肉活动。特别是，该项目还将开发使用该监视器的睡眠分期自动化软件。这一提议的设备将是测试药物突破以及它们如何影响大脑功能，特别是睡眠模式的重要工具。

DESCRIPTION (provided by applicant): This proposed project will develop a small wireless device that is capable of monitoring brain activity (EEG) in mice as well as other physiological signals, such as EMG and ECG. Presently, brain activity is monitored using a cable tethered to the mouse and to the top of the cage, which does not permit natural activity nor any tunnels or most other typical housing accessories. Although new wireless devices have been developed, their sensitivity is not adequate for accurate brain activity monitoring. CleveMed has developed a small wireless monitoring device, the MousePaak(tm), and this proposed project will make that MousePaak even smaller, hence even less obtrusive to the mouse to permit even more natural activity, and add new automated software to provide sleep staging information. This new device and software will be invaluable in testing both the new pharmaceutical breakthroughs for the estimated 40 million individuals in the United States that experience chronic or intermittent sleep-related problems and disorders, and for testing the effect other pharmaceutical breakthroughs might have on normal sleep. The proposed project will develop a wireless solution for monitoring brain and muscle activity of mice both during normal activities and while sleeping. In particular, this project will also develop automated software for sleep staging using this monitor. This proposed device will be an essential tool for testing pharmaceutical breakthroughs and how they affect brain function and especially sleep patterns.