IFN-lambda signal transduction

我们的研究表明，IFN-lambda维持信号转导和转录激活因子STAT1和STAT2的激活时间超过8小时。当被I型ifn激活时，这与这些转录因子的激活谱有显著的不同。有趣的是，I型和III型ifn之间的基因激活动力学是不一样的。相反，I型ifn更早地诱导基因转录，而IFN-lambda介导的基因转录不仅延迟，而且持续时间更长。此外，IFN-lambda对肿瘤细胞的抗增殖作用优于IFN-alpha。这些发现强调了IFN-lambda在癌症治疗中的潜在治疗用途。我们的目标是在小鼠肿瘤模型中测试这种细胞因子的抗肿瘤和抗转移作用。

Our studies show that IFN-lambda sustains the activation of the signal transducers and activators of transcription: STAT1 and STAT2 for longer than 8 hours. This is a striking difference from the activation profile of these transcription factors when activated by type I IFNs. Interestingly the kinetics of gene activation between type I and type III IFNs are not the same. Rather, type I IFNs induce gene transcription earlier while IFN-lambda mediated gene transcription is not only delayed but sustained longer. In addition, IFN-lambda is better than IFN-alpha in inducing an antiproliferative effect on tumor cells. These findings highlight the potential therapeutic use of IFN-lambda in the treatment of cancer. Our goal is to test the antitumor and antimetastatic effects of this cytokine in mouse tumor models.