PRECLINICAL THERAPEUTICS

临床前治疗核心(PCTC)设施产生荷瘤动物并进行临床前研究 加州大学旧金山分校综合癌症中心研究人员的肿瘤学试验。提供各种基于异种移植物的 癌症模型，核心提供的服务包括关于实验设计、肿瘤 培养中的细胞生长和小鼠肿瘤的产生，实验药物的给药，监测 肿瘤负担和对治疗的反应，以及研究结果的解释。PCTC维持一项 来自多种肿瘤类型的常用人类癌细胞株的冷冻库以及数据 关于它们在体内的生长特性，以及用户可以访问的基因工程数据库 加州大学旧金山分校CCC内维护的人类癌症小鼠模型，以促进 积极利用这些模型的实验室，以及有兴趣对其进行临床前试验的研究人员。这个 PCTC也是小动物生存外科专业知识的来源，并可提供以下方面的培训 这些技术在充电的基础上。尽管核心的主要功能是测试实验性抗癌 体内试剂，它还提供了人类癌症的动物模型，用于新的诊断、肿瘤、成像、 和基础机械研究。核心负责监督、维护并以服务的形式提供许多小型 动物成像技术被安置在屏障设施内。集中式细胞和动物的可用性 资源，以及具有进行临床前研究专业知识的人员，确保适当的 实验设计和重复性，符合当地和联邦关于肿瘤生长的法规指南 通过协调动物购买和住房，最大限度地利用资源。

The Preclinical Therapeutics Core (PCTC) facility generates tumor-bearing animals and conducts preclinical oncology trials for UCSF Comprehensive Cancer Center investigators. Offering a variety of xenograft-based cancer models, the core provides services that include consultation regarding experimental design, tumor cell growth in culture and generation of tumors in mice, administration of experimental agents, monitoring of tumor burden and response to therapy, and interpretation of study results. The PCTC maintains a cryorepository of commonly used human cancer cell lines derived from multiple tumor types along with data regarding their in vivo growth characteristics, and a user-accessible data base of genetically-engineered mouse models of human cancer maintained within the UCSF CCC, in order to foster collaboration between labs actively utilizing these models, and investigators interested in undertaking pre-clinical trials thereon. The PCTC is also a resource of expertise in small animal survival surgery, and is available to provide training in these techniques on a recharge basis. Although the core primarily functions to test experimental anti-cancer agents in vivo, it also provides animal models of human cancer for use in novel diagnostic, tumor, imaging, and basic mechanistic research. The core oversees, maintains and provides as a service a number of small animal imaging technologies housed within the barrier facility. The availability of centralized cell and animal resources, together with personnel with expertise in conducting preclinical studies, ensures appropriate experimental design and reproducibility, compliance with local and federal regulatory guidelines for tumorbearing animals, and maximum resource utilization through coordinated animal purchasing and housing.