PROG 8- Hematopoietic Cell Transplantation and

造血细胞移植和免疫重建计划是一个多学科的项目 旨在更好地了解两者背后的生物学机制的努力 自体和异基因造血细胞移植(HCT)。主要研究主题包括 发展对干细胞植入、移植物与宿主之间潜在原理的机械洞察 疾病、移植物与肿瘤反应和免疫重建。将新概念转化为临床 从这些更基础的研究中衍生出来的研究是至关重要的。这些目标的实现是通过参与 由来自四个部门的19名调查人员组成的动态小组，由方案项目(两个POL)支持， 研究人员启动(17个ROL)，临床试验网络(U01)，培训(T32和三个K奖)和 基金会拨款。在有新概念和新想法的地方使用翻译研究的概念 在实验室开发并推广到临床，以及来自临床的见解和推广 对于实验室来说，新的研究途径和干预策略一直并将继续 探索过了。自2000年以来，已出版了180多份与方案目标有关的出版物 同行评议的期刊。该计划招收基础科学家、内科科学家和临床医生 研究人员专注于改善接受HCT的患者的结局这一压倒一切的目标。 我们的愿景是探索成功移植的主要机制，包括植入 造血干细胞、移植物抗肿瘤和移植物抗宿主反应与免疫增强 通过以实验室为基础的项目进行重建，并将其扩展到临床，主要通过 研究人员启动了临床试验。临床策略已经并正在根据 探索主要细胞群体机制的实验室调查包括 造血干细胞、髓系和淋巴系祖细胞、NK、T、NK-T和抗原提呈 细胞。该程序广泛地与基础调查人员和翻译调查人员进行互动 并得到所有癌症中心共享资源的支持，以提供丰富的 发现和临床翻译。

The Program in Hematopoietic Cell Transplantation and Immune Reconstitution is a multidisciplinary effort aimed at developing a better understanding of the biological mechanisms underlying both autologous and allogeneic hematopoietic cell transplantation (HCT). Major themes of research include developing mechanistic insights into the underlying principles of stem cell engraftment, graft vs. host disease, graft vs. tumor reactions and immune reconstitution. Translation of novel concepts to the clinic derived from these more basic studies is of central importance. These goals are achieved by engaging a dynamic group of 19 investigators from four Departments supported by Program Project (two POls), investigator initiated (17 ROls), clinical trials network (U01), training (T32 and three K awards) and Foundation grants. Using the concept of translational research where new concepts and ideas are developed in the laboratory and extended to the clinic, as well as insights from the clinic with extension to the laboratory, novel avenues of research and strategies for intervention have been and continue to be explored. Since 2000, over 180 publications relevant to the goals of the Program have been published in peer-reviewed journals. This Program enlists basic scientists, physician-scientists and clinician investigators centered upon the over-riding goal of improving outcomes for patients undergoing HCT. Our vision is to explore the major mechanisms of successful transplantation including engraftment of hematopoietic stem cells, graft-vs.-tumor and graft-vs.-host reactions and enhancement of immune reconstitution through laboratory-based projects with extension to the clinic through mainly investigator initiated clinical trials. Clinical strategies have and are being developed based upon laboratory investigations to probe mechanisms of the major cellular populations including hematopoietic stem cells, myeloid and lymphoid progenitor cells, NK, T, NK-T and antigen presenting cells. This Program extensively interacts with both basic and translational investigators from a number of different Programs and is supported by all Cancer Center Shared Resources to provide a rich fabric of discovery and clinical translation.