SLEEP AND ABNORMAL BEHAVIOR

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。圈养猕猴长时间被关在一个笼子里，往往会出现非典型的行为，可能表明受到干扰和异常。一种常见的非典型行为是刻板重复运动。不太常见（3-5%）的行为类型是潜在的或实际的自残行为（SIBs）。SIBs包括自咬、长期拔头发或梳理头发、撞头等行为。SIB在不同的动物中可能每天都发生，或者发生的频率要低得多，并且通常对治疗有抗药性。这项研究验证了SIB与睡眠紊乱有关的假设。八对成年猴（束状猴）中，一只在白天表现出SIB，另一只在白天没有表现出SIB。在夜间（房间黑暗）时的运动由红外视频系统检测，该系统激活计算机数字视频记录运动的持续时间。活动的数量被自动记录下来，视频场景由观察者对活动类型进行评分。总的来说，SIB猴子比对照组有更多的夜间清醒时间，持续时间更长。SIB猴通常在活动期间表现出SIB行为。最重要的是，一只从未观察到自咬的对照猴在夜间表现出最多的自咬行为。目前正在对婴儿和幼年猴子进行睡眠观察，以确定夜间活动与白天行为和皮质醇之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Captive macaque monkeys housed for long periods of time in single cages often develop behaviors that are atypical for their species and may indicate disturbance and abnormality. A common atypical behavior is stereotyped repetitive locomotion. A less common (3-5%) behavior type is potential or actual self-injurious behaviors (SIBs). SIBs include actions such as self-biting, chronic hair pulling or grooming, and head banging. SIB may occur daily or much less frequently in different animals, and is often resistant to treatment. This study tested the hypothesis that SIB is correlated with disturbed sleep. Eight pairs of aged adult monkeys (m. fascicularis) included one animal that exhibited daytime SIB and one not seen to exhibit SIB during daytime hours. Movement during night (room dark) hours was detected by an infrared video system, which activated computer digital video recording for the duration of movement. Amount of activity was automatically recorded and video scenes were scored by observers for the type of activity. Overall, SIB monkeys had more night wake periods for longer durations than controls. SIB monkeys often exhibited their SIB behavior during active periods. Of most importance for identifying animals with SIB, one control monkey, never observed to self-bite, exhibited the most self-biting during the night. Sleep observations are currently being followed in infant and juvenile monkeys to determine relationships between night period activity and daytime behavior and cortisol.