ENVIRONMENTAL INFLUENCES ON THE PERINATAL LUNG DEVELOPMENT

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。目的：1. 描述猴在发育关键窗口期（从妊娠早期到出生后13个月）暴露于常见室内空气污染物（ETS）的条件，这些条件与母亲和/或婴儿的超声检查、羊水和血液样本的测量值相关。2. 使用形态学、生理学、生物化学和免疫生物学方法测定影响，以确定关键围产期发育期（从妊娠早期至出生后13个月）暴露于ETS对猴肺的影响。3. 确定相同的围产期ETS暴露是否会增强肺中神经营养因子的产生，并与C纤维中P物质的产生增加相关，从而导致CNS呼吸反应过度。4. 确定围产期后停止暴露于ETS是否会改善影响或与肺及其神经控制的持续变化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: 1. To characterize conditions of exposure to a common indoor air pollutant (ETS) in monkeys during critical windows of development (ranging from early gestation to 13 months postnatal age) correlated to measures from ultrasonography, amniotic fluid and blood samples of the mother and/or infant. 2. To determine the consequences in the lung of exposure to ETS in monkeys during critical perinatal periods of development (from early gestation to 13 months postnatal age) using morphological, physiologic, biochemical and immunobiological approaches to measure effects. 3. To determine if the same perinatal ETS exposure enhances neurotrophin production in the lungs in association with increased production of substance P in C-fibers resulting in exaggerated CNS respiratory responses. 4. To determine if cessation of exposure to ETS after the perinatal period will ameliorate effects or be associated with persistent changes in the lung and its neural control.