MENOPAUSAL HOT FLASHES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。建立更年期潮热的灵长类动物模型。 在美国，超过3000万女性患有更年期潮热，这与严重的不适，睡眠不足，疲劳和可能的抑郁症有关。虽然激素替代疗法是治疗潮热的有效方法，但大多数女性由于害怕癌症而不接受它。更好地了解潮热的原因将有助于开发更好的治疗方法。我们已经证明，潮热是由体温的微小波动触发的，这种波动作用于调节过紧的恒温器。由于恒温器（下丘脑）位于大脑的中间，因此不容易在人类中进行研究。我们正在研究是否可以在更年期的恒河猴模型中复制人类潮热指标，如皮肤温度升高和出汗。这项研究使用WNPRC动物服务和老龄化资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To develop a primate model of menopausal hot flashes. More than 30 million women in the U.S. suffer from menopausal hot flashes, which are associated with severe discomfort, sleep loss, fatigue and, possibly, depression. Although hormone replacement therapy is an effective treatment for hot flashes, most women do not receive it due to a fear of cancer. A better understanding of the causes of hot flashes will aid in the development of improved treatments. We have shown that hot flashes are triggered by small fluctuations in body temperature acting on a thermostat that is too tightly regulated. Since the thermostat (hypothalamus) is located in the middle of the brain, it is not easily studied in humans. We are studying whether we can replicate human indicators of hot flashes, such as increased skin temperature and sweating, in rhesus monkey models of menopause. This research used WNPRC Animal Services and Aging Resources.