LONG-TERM SAFETY AND EFFICACY OF PMPA (TENOFOVIR)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：寻找更好、更安全的抗病毒药物治疗HIV感染。猴免疫缺陷病毒感染新生儿和婴儿猕猴是一种有用的人类艾滋病动物模型，可用于评估新型抗病毒药物。此前，我们启动了评估替诺福韦(9-[2-(膦甲氧基)丙基]腺嘌呤；PMPA)的长期疗效和毒性的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The objective of this project is to find better and safer antiviral drugs to treat HIV infection. Simian immunodeficiency virus infection of newborn and infant macaques is a useful animal model of human AIDS to evaluate novel antiviral drugs. Previously, we initiated studies to evaluate the long-term therapeutic and toxic effects of tenofovir (9-[2-(phosphonomethoxy)-propyl]adenine; PMPA).