NONHUMAN PRIMATE MODEL OF MYCOPLASMA PNEUMONIAE PNEUMONIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本项目目的是建立非人类肺炎支原体肺炎灵长类动物模型。第一步是将纯毒素注射到一只被淘汰狒狒的肺部（第二只被淘汰的狒狒将接受携带者和热灭活毒素，作为对照）。我们将通过定义已知的作为支气管肺泡灌洗（BAL）炎症标志物的细胞因子的作用、它们对组织病理学病变的影响以及毒素在选定组织中的分布来表征炎症反应机制。如果与对照（热灭活毒素）相比，毒素引起了显著的细胞因子反应，我们将申请将活生物体施用于更多的狒狒。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to establish a non-human primate model of Mycoplasma pneumoniae pneumonia. The first step is to administer pure toxin to the lung of a cull baboon (a second cull will receive the carrier plus heat inactivated toxin and serve as the control). We will characterize the inflammatory response mechanism by defining the role of cytokines known to be markers of inflammation in bronchoalveolar lavage (BAL), their influence on histopathologic lesions, and the distribution of toxin in selected tissues. If the toxin elicits a marked cytokine response compared to the control (heat inactivated toxin) we will apply to administer live organism to additional baboons.